Results 201 to 210 of about 1,646,380 (263)

The importance of DNA sequence for nucleosome positioning in transcriptional regulation. [PDF]

Life Sci Alliance
Sahrhage M, Paul NB, Beißbarth T, Haubrock M.   +3 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation. [PDF]

Nat Genet
Linder J, Srivastava D, Yuan H, Agarwal V, Kelley DR.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Hop2-Mnd1 functions as a DNA sequence fidelity switch in Dmc1-mediated DNA recombination. [PDF]

Nat Commun
Peng JC, Chang HY, Sun YL, Prentiss M, Li HW, Chi P.   +5 more
europepmc   +1 more source

DNA Sequence Changes Resulting from Codon Optimization Affect Gene Expression in <i>Pichia pastoris</i> by Altering Chromatin Accessibility. [PDF]

J Fungi (Basel)
Lu C, Guo L, Fang B, Shi J, Zhou M.
europepmc   +1 more source

Fundamentals for predicting transcriptional regulations from DNA sequence patterns. [PDF]

J Hum Genet
Koido M, Tomizuka K, Terao C.
europepmc   +1 more source

Bridging the Gap Between Platforms: Comparing Grape Phylloxera Daktulosphaira vitifoliae (Fitch) Microsatellite Allele Size and DNA Sequence Variation. [PDF]

Insects
Blacket MJ, Piper AM, Hoffmann AA, Cunningham JP, Valenzuela I.   +4 more
europepmc   +1 more source