Results 41 to 50 of about 1,741,840 (332)

Having a direct look:analysis of DNA damage and repair mechanisms by next generation sequencing [PDF]

, 2014
Genetic information is under constant attack from endogenous and exogenous sources, and the use of model organisms has provided important frameworks to understand how genome stability is maintained and how various DNA lesions are repaired. The advance of
Adamo, Ahmed, Alexandrov, Anton Gartner, Bettina Meier, Campbell, Cheung, De Silva, De Stasio, de Wind, Denver, Denver, Drost, Flibotte, Glaab, Greenman, Greenwald, Higgins, Higgins, Klein Douwel, Kong, Koole, Kuraoka, Lee, Lemee, Li, Liu, London, Lowden, McClintock, McClintock, Meier, Muller, Pace, Petitjean, Roerink, Serero, Shima, Shima, Stephens, Stephens, Wu, Youds   +42 more
core   +2 more sources

High‐throughput sequencing approach in analysis of microbial communities colonizing natural gas pipelines

MicrobiologyOpen, 2019
This study provides a deep modern insight into the phylogenetic diversity among bacterial consortia found in working and nonworking high‐methane natural gas pipelines located in Poland.
Agnieszka Staniszewska, Alina Kunicka‐Styczyńska, Anna Otlewska, Jan Gawor, Robert Gromadka, Karolina Żuchniewicz, Krzysztof Ziemiński   +6 more
doaj   +1 more source

Optimization of DNA extraction from human urinary samples for mycobiome community profiling. [PDF]

, 2019
IntroductionRecent data suggest the urinary tract hosts a microbial community of varying composition, even in the absence of infection. Culture-independent methodologies, such as next-generation sequencing of conserved ribosomal DNA sequences, provide an
Ackerman, A Lenore, Ackerman, James E, Anger, Jennifer Tash, Freeman, Michael R, Khalique, Muhammad Umair, Kim, Jayoung, NIH Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP), Tang, Jie, Underhill, David M   +8 more
core   +3 more sources

Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease

npj Parkinson's Disease, 2021
Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure.
Sebastiaan P. van Kessel, Petri Auvinen, Filip Scheperjans, Sahar El Aidy   +3 more
doaj   +1 more source

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]

, 2010
Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah, Arlett, Colin F., Bourton, E.C, Clingen, Peter H., Green, M H, Makarov, E.M., Newbold, R.F, Parris, C.N., Plowman, P.N, Themis, M.   +9 more
core   +1 more source

Nostoc edaphicum CCNP1411 from the Baltic Sea—A New Producer of Nostocyclopeptides

Marine Drugs, 2020
Nostocyclopeptides (Ncps) constitute a small class of nonribosomal peptides, exclusively produced by cyanobacteria of the genus Nostoc. The peptides inhibit the organic anion transporters, OATP1B3 and OATP1B1, and prevent the transport of the toxic ...
Anna Fidor, Michał Grabski, Jan Gawor, Robert Gromadka, Grzegorz Węgrzyn, Hanna Mazur-Marzec   +5 more
doaj   +1 more source

DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML [PDF]

, 2014
<b>Background</b>. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors (DNMTi), 5-azacytidine (AzaC) and 5-aza-2’-deoxycytidine (Decitabine),
Adams, Peter, Clark, William, Cole, John, Copland, Mhairi, Edwards, John R., Lund, Kristin, McBryan, Tony, Pchelintsev, Nikolay A., VanderKraats, Nathan D.   +8 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Evolution of genome sequencing techniques [PDF]

, 2016
The quality and the speed for genome sequencing has advanced at the same time that technology boundaries are stretched. This advancement has been divided so far in three generations.
Goebel Vázquez, Cristina, Henao Mejía, Luisa Maria   +1 more
core  

The future of DNA sequencing [PDF]

Nature, 2017
Eric D. Green, Edward M. Rubin and Maynard V. Olson speculate on the next forty years of the applications, from policing to data storage.
Edward M. Rubin, Eric D. Green, Maynard V. Olson   +2 more
openaire   +2 more sources