Results 141 to 150 of about 699,127 (245)

Correction to: DeSP: a systematic DNA storage error simulation pipeline. [PDF]

BMC Bioinformatics, 2022
Yuan L, Xie Z, Wang Y, Wang X.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Efficient trace reconstruction in DNA storage systems using bidirectional beam search. [PDF]

iScience
Gu Z, Xin H, Sharma P, Goh GY, Wong L, Nagarajan N.   +5 more
europepmc   +1 more source

DNA-Aeon provides flexible arithmetic coding for constraint adherence and error correction in DNA storage. [PDF]

Nat Commun, 2023
Welzel M, Schwarz PM, Löchel HF, Kabdullayeva T, Clemens S, Becker A, Freisleben B, Heider D.   +7 more
europepmc   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Efficient pathogen screening in honey bees: Application of FTA® cards for DNA storage and PCR analysis. [PDF]

PLoS One
Myslínová K, Dostálková S, Jemelková J, Hurychová B, Biemann O, Brus J, Fürstová J, Petřivalský M, Danihlík J.   +8 more
europepmc   +1 more source

Adaptive coding for DNA storage with high storage density and low coverage. [PDF]

NPJ Syst Biol Appl, 2022
Cao B, Zhang X, Cui S, Zhang Q.
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Empowering low-crosstalk, dynamic-decision random access of DNA storage via 384-multiplexed nanopore signatures. [PDF]

Nat Commun
Li J, Zhao X, Fan Q, Long Y, Liu R, Zhai J, Pan Q, Li Y.   +7 more
europepmc   +1 more source

High-scale random access on DNA storage systems. [PDF]

NAR Genom Bioinform, 2022
El-Shaikh A, Welzel M, Heider D, Seeger B.   +3 more
europepmc   +1 more source