Results 71 to 80 of about 329,036 (249)
Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system
Nature CommunicationsDNA data storage is a potential alternative to magnetic tape for archival storage purposes, promising substantial gains in information density. Critical to the success of DNA as a storage media is an understanding of the role of environmental factors on ...
Christopher N. Takahashi +9 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2020 Aim. To study the effect of the shelf life of frozen whole blood samples in a biobank on the amount of released deoxyribonucleic acid (DNA).Material and methods.
O. P. Skirko +9 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Novel DNA‐Based Dual‐Mode Data Storage System with Interrelated Concise and Detailed Data
Small ScienceDNA has emerged as a promising storage medium to meet the soaring need for archival data storage because of its exceptional storage density and stability.
Ben Pei +8 more
doaj +1 more source
DSI-ResCNN: A Framework Enhancing the Error-Tolerance Capacity of DNA Storage for Images
IEEE AccessTraditional silicon-based storage technologies have reached a bottleneck with the dramatic increase in global data storage demands. High energy consumption, limited natural resources, and environmental concerns are some of the key reasons.
Cihan Ruan +7 more
doaj +1 more source
Journal of Biological Engineering, 2019 Background With the inherent high density and durable preservation, DNA has been recently recognized as a distinguished medium to store enormous data over millennia.
Yixin Wang +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source