Results 91 to 100 of about 699,352 (277)

Rates of DNA Sequence Profiles for Practical Values of Read Lengths

, 2016
A recent study by one of the authors has demonstrated the importance of profile vectors in DNA-based data storage. We provide exact values and lower bounds on the number of profile vectors for finite values of alphabet size $q$, read length $\ell$, and ...
Chang, Zuling, Chrisnata, Johan, Ezerman, Martianus Frederic, Kiah, Han Mao   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dna-storalator: a computational simulator for DNA data storage

BMC Bioinformatics
Background DNA data storage is an emerging technology that caught the attention of many researchers and engineers. This technology uses DNA molecules as a storage medium and thus presents an extremely dense and durable storage device. However, the unique
Gadi Chaykin, Omer Sabary, Nili Furman, Dvir Ben Shabat, Eitan Yaakobi   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system

Nature Communications
DNA data storage is a potential alternative to magnetic tape for archival storage purposes, promising substantial gains in information density. Critical to the success of DNA as a storage media is an understanding of the role of environmental factors on ...
Christopher N. Takahashi, David P. Ward, Carlo Cazzaniga, Christopher Frost, Paolo Rech, Kumkum Ganguly, Sean Blanchard, Steve Wender, Bichlien H. Nguyen, Jake A. Smith   +9 more
doaj   +1 more source

Dynamic DNA-based information storage [PDF]

, 2019
AbstractTechnological leaps are often driven by key innovations that transform the underlying architectures of systems. Current DNA storage systems largely rely on polymerase chain reaction, which broadly informs how information is encoded, databases are organized, and files are accessed.
Lin, Kevin N., Keung, Albert J., Tuck, James M.   +2 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

High capacity DNA data storage with variable-length Oligonucleotides using repeat accumulate code and hybrid mapping

Journal of Biological Engineering, 2019
Background With the inherent high density and durable preservation, DNA has been recently recognized as a distinguished medium to store enormous data over millennia.
Yixin Wang, Md Noor-A-Rahim, Jingyun Zhang, Erry Gunawan, Yong Liang Guan, Chueh Loo Poh   +5 more
doaj   +1 more source

Shelf life of whole blood samples in a biobank and the yield of deoxyribonucleic acid during genetic testing

Кардиоваскулярная терапия и профилактика, 2020
Aim. To study the effect of the shelf life of frozen whole blood samples in a biobank on the amount of released deoxyribonucleic acid (DNA).Material and methods.
O. P. Skirko, A. N. Meshkov, I. A. Efimova, V. A. Kutsenko, A. V. Kiseleva, M. S. Pokrovskaya, O. V. Kurilova, E. A. Sotnikova, M. V. Klimushina, O. M. Drapkina   +9 more
doaj   +1 more source