Results 111 to 120 of about 2,195,182 (275)

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex [PDF]

, 2010
hSSB1 is a newly discovered single-stranded DNA (ssDNA)-binding protein that is essential for efficient DNA double-strand break signalling through ATM. However, the mechanism by which hSSB1 functions to allow efficient signalling is unknown.
Cubeddu, Liza (R16726), Prise, Kevin M., Schettino, Giuseppe, So, Sairei, Bolderson, Emma, Kevin M. Prise, Derek J. Richard, Cubeddu, Liza, Kerry Richard, White, Malcolm F., Emma Bolderson, David J. Chen, Mihaela Ghita, Kienan Savage, Giuseppe Schettino, Savage, Kienan, Richard, Kerry, Khanna, Kum Kum, Ghita, Mihaela, Malcolm F. White, Sairei So, Richard, Derek J., Kum Kum Khanna, Chen, David J., Liza Cubeddu, Prise, Kevin; id_orcid, Kerry, Richard, Emma, Bolderson, Chen David, J., Kum, Khanna Kum, White Malcolm, F., Liza, Cubeddu, Richard Derek, J., Sairei, So, White, Malcolm F.; id_orcid   +34 more
core   +2 more sources

A Coupled Reconfiguration Mechanism for Single-Stranded DNA Strand Displacement Systems.

, 2022
DNA Strand Displacement (DSD) systems model basic reaction rules, such as toehold-mediated strand displacement and 4-way branch migration, that modify complexes of bound DNA strands. DSD systems have been widely used to design and reason about the correctness of molecular programs, including implementations of logic circuits, neural networks, and ...
Johnson, Hope Amber, Condon, Anne
openaire   +3 more sources

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Twinkle-Catalyzed Toehold-Mediated DNA Strand Displacement Reaction. [PDF]

J Am Chem Soc, 2023
Singh A, Patel G, Patel SS.
europepmc   +1 more source

Sequential Super-Resolution Imaging using DNA Strand Displacement

, 2017
Sequential labeling and imaging in fluorescence microscopy allows the imaging of multiple structures in the same cell using a single fluorophore species.
Cheyenne Martin, Farzin Farzam, Sandeep Pallikkuth, Diane S. Lidke, Mathew R. Lakin, Keith A. Lidke, Jeremy S. Edwards   +6 more
core   +1 more source

Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules [PDF]

, 1993
The frequency of DNA double-strand breaks (dsb) was determined in yeast cells exposed to γ-rays under anoxic conditions. Genomic DNA of treated cells was separated by pulsed field gel electrophoresis, and two different approaches for the evaluation of ...
Beisker, W., Eckardt-Schupp, F., Kellerer, Albrecht M., Eckard-Schupp, F., Friedl, A.A., Kellerer, A.M., Hahn, K.R., Friedl, Anna A., Hahn, K., K. Hahn, A.M. Kellerer, F. Eckardt-Schupp, A.A. Friedl, W. Beisker   +13 more
core   +1 more source

Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

Nature Communications, 2017
DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagereet al.
Anupama J. Thubagere, Chris Thachuk, Joseph Berleant, Robert F. Johnson, Diana A. Ardelean, Kevin M. Cherry, Lulu Qian   +6 more
doaj   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Data for Synthesis and Analysis of Biomolecular Circuits using DNA Strand Displacement

, 2022
Supplementary materials supporting PhD thesis submission titled "Synthesis and Analysis of Biomolecular Circuits using DNA Strand ...
Eyriay, Iuliia
core  

Strand Displacement Activity of PrimPol

, 2020
Human PrimPol is a unique enzyme possessing DNA/RNA primase and DNA polymerase activities. In this work, we demonstrated that PrimPol efficiently fills a 5-nt gap and possesses the conditional strand displacement activity stimulated by Mn2+ ions and ...
Ekaterina A. Maltseva, Olga I. Lavrik, Svetlana N. Khodyreva, Diana I. Gagarinskaya, Elizaveta O. Boldinova, Alena V. Makarova, Ekaterina A. Belousova   +6 more
core   +1 more source