Results 91 to 100 of about 37,201 (270)

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Toehold-Mediated Nonenzymatic DNA Strand Displacement As a Platform for DNA Genotyping

, 2016
Toehold-mediated DNA strand displacement provides unique advantages in the construction and manipulation of multidimensional DNA nanostructures as well as nucleic acid sequence analysis.
Anastasia S. Khodakova (612951), Amanda V. Ellis (1473709), Adrian Linacre (612954), Dmitriy A. Khodakov (1969249)   +3 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Structural mechanism of strand exchange by the RAD51 filament

eLife
Homologous recombination (HR) preserves genomic stability by repairing double-strand DNA breaks and ensuring efficient DNA replication. Central to HR is the strand-exchange reaction taking place within the three-stranded synapsis wherein a RAD51 ...
Luay Joudeh, Robert E Appleby, Joseph D Maman, Luca Pellegrini   +3 more
doaj   +1 more source

High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis

Nature Communications, 2019
Current DNA computational systems are constrained by integration efficiency, device structures and limited functions. Here the authors design a DNA arithmetic logic unit that uses polymerase-mediated strand displacement.
Haomiao Su, Jinglei Xu, Qi Wang, Fuan Wang, Xiang Zhou   +4 more
doaj   +1 more source

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

, 2007
The mechanism of mitochondrial DNA replication is a subject of intense debate. One model proposes a strand-asynchronous replication in which both strands of the circular genome are replicated semi-independently while the other model proposes both a ...
Wanrooij, S, Yasukawa, T, Spelbrink, JN, Goffart, S, Pohjoismäki, JLO   +4 more
core  

Controlling DNA–RNA strand displacement kinetics with base distribution

DNA–RNA hybrid strand displacement underpins the function of many natural and engineered systems. Understanding and controlling factors affecting DNA–RNA strand displacement reactions is necessary to enable control of processes such as CRISPR-Cas9 gene ...
Doye, Jonathan P. K., Louis, Ard A., Bath, Jonathan, Ratajczyk, Eryk J., Šulc, Petr, Turberfield, Andrew J.   +5 more
core   +1 more source

DNA Tetraplexes-Based Toehold Activation for Controllable DNA Strand Displacement Reactions

, 2016
Most of the dynamic DNA devices are rationally constructed by utilizing toehold-mediated DNA strand displacement reactions. However, such approaches have been mainly limited to the operation with double-stranded hybridization and lack the versatility of ...
Na Li (6550), Dingzhong Wang (1910710), Wei Tang (53470), Yan Zhao (58882), Feng Liu (72874), Huaming Wang (525313)   +5 more
core   +1 more source

Molecular basis for DNA strand displacement by NHEJ repair polymerases [PDF]

, 2015
The non-homologous end-joining (NHEJ) pathway repairs DNA double-strand breaks (DSBs) in all domains of life. Archaea and bacteria utilize a conserved set of multifunctional proteins in a pathway termed Archaeo-Prokaryotic (AP) NHEJ that facilitates DSB ...
Plocinski, Przemyslaw, Przemyslaw Plocinski (246226), Aidan Doherty (4461097), Carlberg, Tom, Edward J Bartlett (9166328), Brissett, Nigel; id_orcid, Nigel Brissett (4461499), Tom Carlberg (16228190), Doherty, Aidan J., J. Bartlett, Edward   +9 more
core   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source