Results 71 to 80 of about 78,386 (303)
DNA logic gate based on metallo-toehold strand displacement.
PLoS ONE, 2014 DNA is increasingly being used as an ideal material for the construction of nanoscale structures, circuits, and machines. Toehold-mediated DNA strand displacement reactions play a very important role in these enzyme-free constructions. In this study, the
Wei Deng +3 more
doaj +1 more source
Remote Toehold: A Mechanism for Flexible Control of DNA Hybridization Kinetics [PDF]
, 2011 Hybridization of DNA strands can be used to build molecular devices, and control of the kinetics of DNA hybridization is a crucial element in the design and construction of functional and autonomous devices. Toehold-mediated strand displacement
Bath, Jonathan +3 more
core +1 more source
, 2010 We propose a novel theoretical biomolecular design to implement any Boolean circuit using the mechanism of DNA strand displacement. The design is scalable: all species of DNA strands can in principle be mixed and prepared in a single test tube, rather ...
A. Goel +8 more
core +2 more sources
Statistical Mechanics of thermal denaturation of DNA oligomers [PDF]
, 2003 Double stranded DNA chain is known to have nontrivial elasticity. We study the effect of this elasticity on the denaturation profile of DNA oligomer by constraining one base pair at one end of the oligomer to remain in unstretched (or intact) state.
Singh, Navin, Singh, Yashwant
core +2 more sources
Robustness of DNA Strand Displacement Systems⋆
IFAC-PapersOnLine, 2018 Abstract How to construct a reliable deoxyribonucleic acid (DNA) circuit is one of the most important issues in the field of molecular programming and computing. Such a circuit frequently suffers from various kinds of unintended binding reactions on account of a lower specificity of the molecular interaction emerging from base complementarity between
Takashi Nakakuki +3 more
openaire +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Frontiers in Microbiology, 2014 Replication slippage or slipped-strand mispairing involves the misalignment of DNA strands during the replication of repeated DNA sequences, and can lead to genetic rearrangements such as microsatellite instability.
Melissa G. eCastillo-Lizardo +2 more
doaj +1 more source
Bubble dynamics in double stranded DNA : A Rouse chain based approach
, 2010 We propose a model for the fluctuation dynamics of the local denaturation zones (bubbles) in double-stranded DNA. In our formulation, the DNA strand is model as a one dimensional Rouse chain confined at both the ends.
Chakrabarti, Rajarshi
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?
Intelligent ComputingThis review article poses the overarching question: Can complex dynamic DNA nanodevices based on strand displacement reactions be operated within, and can they interoperate with living cells?
Hyeyun Jung +3 more
doaj +1 more source