Results 61 to 70 of about 2,195,182 (275)

Strand Displacement of Double-Stranded DNA by Triplex-Forming Antiparallel Purine-Hairpins [PDF]

Oligonucleotides, 2005
We characterize the binding affinity and the thermodynamics of hybridization of triplex-forming antiparallel purine-hairpins composed of two antiparallel purine domains linked by a loop directed toward single-stranded and double-stranded DNA (ssDNA, dsDNA).
Coma, Sílvia, Eritja Casadellà, Ramón, Noé, Véronique, Ciudad, Carlos J.   +3 more
openaire   +3 more sources

From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?

Intelligent Computing
This review article poses the overarching question: Can complex dynamic DNA nanodevices based on strand displacement reactions be operated within, and can they interoperate with living cells?
Hyeyun Jung, Ethan Collinson, Alexander Patrick Hawes, Harold Fellermann   +3 more
doaj   +1 more source

Enabling programmable dynamic DNA chemistry using small-molecule DNA binders

Nature Communications, 2023
The binding of small molecules to the double helical structure of DNA, through either intercalation or minor groove binding, may significantly alter the stability and functionality of DNA, which is a fundamental basis for many therapeutic and sensing ...
Junpeng Xu, Guan Alex Wang, Lu Gao, Lang Wu, Qian Lei, Hui Deng, Feng Li   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Strong sequence-dependence in RNA/DNA hybrid strand displacement kinetics [PDF]

Strand displacement reactions underlie dynamic nucleic acid nanotechnology. The kinetic and thermodynamic features of DNA-based displacement reactions are well understood and well predicted by current computational models. By contrast, understanding of
Ouldridge, Thomas E., Jurinovic, Krizan, Goetz, John, Ouldridge, Thomas, Smith, Francesca G., Smith, Francesca, Stevens, molly, Goertz, John P., Stevens, Molly M.   +8 more
core   +1 more source

Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase

Nature Communications
Members of the Pol A family of DNA polymerases, found across all domains of life, utilize various strategies for DNA strand separation during replication.
Ashok R. Nayak, Viktoriia Sokolova, Sirelin Sillamaa, Karl Herbine, Juhan Sedman, Dmitry Temiakov   +5 more
doaj   +1 more source

Catalytic DNA Strand Displacement Cascades Applied to Logic Programming

IEEE Access, 2019
The field of DNA computing is devoted to the creation of devices capable of processing information signals encoded on biological substrates. These signals are intended to propagate in cascades of biochemical reactions in which they naturally undergo a ...
Nelson E. Ordonez-Guillen, Israel M. Martinez-Perez   +1 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source