Results 51 to 60 of about 37,201 (270)

Rational Design of pH-Controlled DNA Strand Displacement [PDF]

Journal of the American Chemical Society, 2014
Achieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solution's pH, over an ...
Amodio, A, Zhao, B, Porchetta, A, Idili, A, Castronovo, M, Fan, C, RICCI, FRANCESCO   +6 more
openaire   +4 more sources

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

Frontiers in Bioengineering and Biotechnology, 2023
In this work, gold nanoparticles@Ti3C2 MXenes nanocomposites with excellent properties were combined with toehold-mediated DNA strand displacement reaction to construct an electrochemical circulating tumor DNA biosensor.
Xiongtao Yu, Silan Bai, Lishi Wang
doaj   +1 more source

Irreversible DNA strand displacement.

, 2014
Irreversible DNA strand displacement.
Zhiyu Wang (282312), Tao Song (130854), Chenyan Deng (642884), Xiaolong Shi (412458), Zhihua Chen (165630), Linqiang Pan (553947)   +5 more
core   +1 more source

Strand Displacement of Double-Stranded DNA by Triplex-Forming Antiparallel Purine-Hairpins [PDF]

Oligonucleotides, 2005
We characterize the binding affinity and the thermodynamics of hybridization of triplex-forming antiparallel purine-hairpins composed of two antiparallel purine domains linked by a loop directed toward single-stranded and double-stranded DNA (ssDNA, dsDNA).
Coma, Sílvia, Eritja Casadellà, Ramón, Noé, Véronique, Ciudad, Carlos J.   +3 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

DNA logic gate based on metallo-toehold strand displacement.

PLoS ONE, 2014
DNA is increasingly being used as an ideal material for the construction of nanoscale structures, circuits, and machines. Toehold-mediated DNA strand displacement reactions play a very important role in these enzyme-free constructions. In this study, the
Wei Deng, Huaguo Xu, Wei Ding, Haojun Liang   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Information-based autonomous reconfiguration in systems of interacting DNA nanostructures

Nature Communications, 2018
Strand displacement is commonly used in DNA nanotechnology to program dynamic interactions between individual DNA strands. Here, the authors describe a tile displacement principle that is similar in concept but occurs on a larger structural level: the ...
Philip Petersen, Grigory Tikhomirov, Lulu Qian   +2 more
doaj   +1 more source

Replication slippage of the thermophilic DNA polymerases B and D from the Euryarchaeota Pyrococcus abyssi

Frontiers in Microbiology, 2014
Replication slippage or slipped-strand mispairing involves the misalignment of DNA strands during the replication of repeated DNA sequences, and can lead to genetic rearrangements such as microsatellite instability.
Melissa G. eCastillo-Lizardo, Ghislaine eHenneke, Enrique eViguera   +2 more
doaj   +1 more source