Results 41 to 50 of about 35,316 (244)

Rational Design of pH-Controlled DNA Strand Displacement [PDF]

Journal of the American Chemical Society, 2014
Achieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solution's pH, over an ...
Amodio, A, Zhao, B, Porchetta, A, Idili, A, Castronovo, M, Fan, C, RICCI, FRANCESCO   +6 more
openaire   +4 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

DNA logic gate based on metallo-toehold strand displacement.

PLoS ONE, 2014
DNA is increasingly being used as an ideal material for the construction of nanoscale structures, circuits, and machines. Toehold-mediated DNA strand displacement reactions play a very important role in these enzyme-free constructions. In this study, the
Wei Deng, Huaguo Xu, Wei Ding, Haojun Liang   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Information-based autonomous reconfiguration in systems of interacting DNA nanostructures

Nature Communications, 2018
Strand displacement is commonly used in DNA nanotechnology to program dynamic interactions between individual DNA strands. Here, the authors describe a tile displacement principle that is similar in concept but occurs on a larger structural level: the ...
Philip Petersen, Grigory Tikhomirov, Lulu Qian   +2 more
doaj   +1 more source

Replication slippage of the thermophilic DNA polymerases B and D from the Euryarchaeota Pyrococcus abyssi

Frontiers in Microbiology, 2014
Replication slippage or slipped-strand mispairing involves the misalignment of DNA strands during the replication of repeated DNA sequences, and can lead to genetic rearrangements such as microsatellite instability.
Melissa G. eCastillo-Lizardo, Ghislaine eHenneke, Enrique eViguera   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?

Intelligent Computing
This review article poses the overarching question: Can complex dynamic DNA nanodevices based on strand displacement reactions be operated within, and can they interoperate with living cells?
Hyeyun Jung, Ethan Collinson, Alexander Patrick Hawes, Harold Fellermann   +3 more
doaj   +1 more source

Enabling programmable dynamic DNA chemistry using small-molecule DNA binders

Nature Communications, 2023
The binding of small molecules to the double helical structure of DNA, through either intercalation or minor groove binding, may significantly alter the stability and functionality of DNA, which is a fundamental basis for many therapeutic and sensing ...
Junpeng Xu, Guan Alex Wang, Lu Gao, Lang Wu, Qian Lei, Hui Deng, Feng Li   +6 more
doaj   +1 more source