Results 21 to 30 of about 78,386 (303)

8-Bit Adder and Subtractor with Domain Label Based on DNA Strand Displacement [PDF]

open access: yesMolecules, 2018
DNA strand displacement, which plays a fundamental role in DNA computing, has been widely applied to many biological computing problems, including biological logic circuits.
Weixuan Han, Changjun Zhou
doaj   +2 more sources

Mechanism of strand displacement synthesis by DNA replicative polymerases [PDF]

open access: yesNucleic Acids Research, 2016
Replicative holoenzymes exhibit rapid and processive primer extension DNA synthesis, but inefficient strand displacement DNA synthesis. We investigated the bacteriophage T4 and T7 holoenzymes primer extension activity and strand displacement activity on ...
Allemand, Jean-François   +6 more
core   +4 more sources

A CRISPR–Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection [PDF]

open access: goldNature Communications, 2018
Isothermal DNA amplification techniques are useful for diagnostic applications in place of traditional PCR. Here the authors describe CRISDA, which combines CRISPR–Cas9 with strand displacement amplification and exhibits attomolar sensitivity and single ...
Wenhua Zhou   +5 more
doaj   +2 more sources

Timed Pulses in DNA Strand Displacement Reactions. [PDF]

open access: yesJ Am Chem Soc, 2023
Inspired by naturally occurring regulatory mechanisms that allow complex temporal pulse features with programmable delays, we demonstrate here a strategy to achieve temporally programmed pulse output signals in DNA-based strand displacement reactions (SDRs).
Bucci J   +4 more
europepmc   +4 more sources

Design of DNA Strand Displacement Reactions [PDF]

open access: greenCurrent Opinion in Biotechnology
DNA strand displacement (SD) reactions are central to the operation of many synthetic nucleic acid systems, including molecular circuits, sensors, and machines. Over the years, a broad set of design frameworks has emerged to accommodate various functional goals, initial configurations, and environmental conditions. Nevertheless, key challenges persist,
Križan Jurinović   +3 more
openalex   +4 more sources

On the Biophysics and Kinetics of Toehold-Mediated DNA Strand Displacement [PDF]

open access: yesNucleic Acids Research, 2013
Dynamic DNA nanotechnology often uses toehold-mediated strand displacement for controlling reaction kinetics. Although the dependence of strand displacement kinetics on toehold length has been experimentally characterized and phenomenologically modeled ...
Yurke, Bernard
core   +5 more sources

Modular DNA strand-displacement controllers for directing material expansion [PDF]

open access: yesNature Communications, 2018
Materials which change shape in response to a trigger are of interest for soft robotics and targeted therapeutic delivery. Here, the authors report on the development of DNA-crosslinked hydrogels which can expand upon the detection of different ...
Joshua Fern, Rebecca Schulman
doaj   +2 more sources

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