Leak-Resistant Design of DNA Strand Displacement Systems [PDF]
, 2020 Although a number of dynamically-controlled nanostructures and programmable DNA Strand Displacement (DSD) systems have been designed using DNA strand displacement, predictability and scalability of these DNA-based systems remain limited due to leakages ...
Vinay Gautam, Gautam, Vinay
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Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases [PDF]
Nature Communications, 2023 Rational design of self-assembled DNA nanostructures has become one of the fastest-growing research areas in molecular science. Particular attention is focused on the development of dynamic DNA nanodevices whose configuration and function are regulated ...
Yusuke Takezawa +6 more
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A Novel Computational Method to Reduce Leaky Reaction in DNA Strand Displacement [PDF]
Journal of Analytical Methods in Chemistry, 2015 DNA strand displacement technique is widely used in DNA programming, DNA biosensors, and gene analysis. In DNA strand displacement, leaky reactions can cause DNA signals decay and detecting DNA signals fails.
Xin Li +5 more
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Characterization and engineering of a DNA polymerase reveals a single amino-acid substitution in the fingers subdomain to increase strand-displacement activity of A-family prokaryotic DNA polymerases [PDF]
BMC Molecular and Cell Biology, 2019 Background The discovery of thermostable DNA polymerases such as Taq DNA polymerase revolutionized amplification of DNA by polymerase chain reaction methods that rely on thermal cycling for strand separation.
Yvonne Piotrowski +2 more
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Double Synchronization Based on DNA Strand Displacement Reaction [PDF]
IEEE Access, 2020 As an important part of biological computing, DNA strand displacement technology is used to construct complex biochemical circuits. Reversible molecular chemical reactions are basic chemical reactions.
Junwei Sun +3 more
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Sequential super-resolution imaging using DNA strand displacement. [PDF]
PLoS ONE, 2018 Sequential labeling and imaging in fluorescence microscopy allows the imaging of multiple structures in the same cell using a single fluorophore species.
Sandeep Pallikkuth +6 more
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Molecular Full Adder Based on DNA Strand Displacement [PDF]
IEEE Access, 2020 A new method, namely DNA strand displacement (DSD), has recently emerged in the field of biocomputing. DSD uses the toehold domain as a starting point to cover the strand in the migration domain.
Wei Xiao +4 more
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Regulation of DNA Strand Displacement Using an Allosteric DNA Toehold
Journal of the American Chemical Society, 2016 Toehold-mediated DNA strand displacement is the fundamental basis for the construction and operation of diverse DNA devices, including circuits, machines, sensors, and reconfigurable structures.
Yanan Tang (813663) +3 more
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Strand displacement synthesis by yeast DNA polymerase epsilon [PDF]
Nucleic Acids Research, 2016 DNA polymerase epsilon (Pol epsilon) is a replicative DNA polymerase with an associated 3'aEuro"5' exonuclease activity. Here, we explored the capacity of Pol epsilon to perform strand displacement synthesis, a process that influences many DNA ...
Ganai, Rais A., +6 more
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Orthogonal Enzyme-Driven Timers for DNA Strand Displacement Reactions. [PDF]
J Am Chem Soc, 2022 Here we demonstrate a strategy to rationally program a delayed onset of toehold-mediated DNA strand-displacement reactions. The approach is based on blocker strands that efficiently inhibit the strand displacement by binding to the toehold domain of the ...
Bucci J +4 more
europepmc +4 more sources