Results 11 to 20 of about 2,195,182 (275)
Timed Pulses in DNA Strand Displacement Reactions. [PDF]
J Am Chem Soc, 2023 Inspired by naturally occurring regulatory mechanisms that allow complex temporal pulse features with programmable delays in gene expression and biological pathways, we demonstrate here a strategy to achieve temporally programmed pulse output signals in ...
Bucci J +4 more
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Orthogonal Enzyme-Driven Timers for DNA Strand Displacement Reactions. [PDF]
J Am Chem Soc, 2022 Here we demonstrate a strategy to rationally program a delayed onset of toehold-mediated DNA strand-displacement reactions. The approach is based on blocker strands that efficiently inhibit the strand displacement by binding to the toehold domain of the ...
Bucci J +4 more
europepmc +6 more sources
DNA Strand-Displacement Temporal Logic Circuits. [PDF]
J Am Chem Soc, 2022 Molecular circuits capable of processing temporal information are essential for complex decision making in response to both the presence and history of a molecular environment. A particular type of temporal information that has been recognized to be important is the relative timing of signals.
Lapteva AP, Sarraf N, Qian L.
europepmc +4 more sources
First passage time study of DNA strand displacement. [PDF]
Biophys J, 2021 Abstract DNA strand displacement, where a single-stranded nucleic acid invades a DNA duplex, is pervasive in genomic processes and DNA engineering applications. The kinetics of strand displacement have been studied in bulk; however, the kinetics of the underlying strand exchange were obfuscated by a slow bimolecular association step ...
Broadwater DWB, Cook AW, Kim HD.
europepmc +7 more sources
DNA strand displacement based computational systems and their applications [PDF]
Frontiers in Genetics, 2023 DNA computing has become the focus of computing research due to its excellent parallel processing capability, data storage capacity, and low energy consumption characteristics.
Congzhou Chen +4 more
doaj +2 more sources
Kinetics and Activation Strategies in Toehold-Mediated and Toehold-Free DNA Strand Displacement [PDF]
BiosensorsNucleic acid strand displacement reactions (SDRs) are fundamental building blocks of dynamic DNA nanotechnology. A detailed understanding of their kinetics is crucial for designing efficient sequences and regulating reaction networks with applications in
Yuqin Wu +4 more
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A Novel Computational Method to Reduce Leaky Reaction in DNA Strand Displacement [PDF]
Journal of Analytical Methods in Chemistry, 2015 DNA strand displacement technique is widely used in DNA programming, DNA biosensors, and gene analysis. In DNA strand displacement, leaky reactions can cause DNA signals decay and detecting DNA signals fails.
Xin Li +5 more
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DNA dynamics and computation based on toehold-free strand displacement
Nature Communications, 2021 Synthetic DNA constructs can to used to recognise and respond to input signals. Here the authors present complex DNA nanostructures with toehold-free strand displacement for generation of ON/OFF switches and Boolean gates.
Hong Kang +5 more
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Scalable DNA recognition circuits based on DNA strand displacement. [PDF]
Nanoscale AdvA scalable recognition circuit was designed and implemented using DNA and eventually a molecular comparator was constructed.
Wang F +5 more
europepmc +3 more sources
Leak-Resistant Design of DNA Strand Displacement Systems [PDF]
, 2020 Although a number of dynamically-controlled nanostructures and programmable DNA Strand Displacement (DSD) systems have been designed using DNA strand displacement, predictability and scalability of these DNA-based systems remain limited due to leakages ...
Vinay Gautam, Gautam, Vinay
core +4 more sources