Results 151 to 160 of about 3,135 (178)
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Science, 2012
Watching Supercoiled DNA The DNA double helix can undergo additional twisting, or supercoiling, that plays a role in transciption and protein binding, in part by bringing distant DNA locations together.
M. T. J. van Loenhout +2 more
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Watching Supercoiled DNA The DNA double helix can undergo additional twisting, or supercoiling, that plays a role in transciption and protein binding, in part by bringing distant DNA locations together.
M. T. J. van Loenhout +2 more
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Biophysical Chemistry, 1988
DNA topoisomerase mutants of Escherichia coli and Saccharomyces cerevisiae were used to study the topological state of intracellular DNA. In E. coli, it is shown that switching off the gene topA encoding DNA topoisomerase I leads to an increase in the degree of negative supercoiling of intracellular DNA and inhibition of the growth of the cells: a d ...
G N, Giaever, L, Snyder, J C, Wang
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DNA topoisomerase mutants of Escherichia coli and Saccharomyces cerevisiae were used to study the topological state of intracellular DNA. In E. coli, it is shown that switching off the gene topA encoding DNA topoisomerase I leads to an increase in the degree of negative supercoiling of intracellular DNA and inhibition of the growth of the cells: a d ...
G N, Giaever, L, Snyder, J C, Wang
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Transcription and DNA supercoiling
Current Opinion in Genetics & Development, 1993Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells.
J C, Wang, A S, Lynch
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DNA supercoiling in apoptotic chromatin [PDF]
Biochemical and Biophysical Research Communications, 2003 In a previous paper, we have reported that in rat thymocyte apoptosis chromatin undergoes a specific structural change as well as an appreciable increase in the unacetylated forms of histones H3 and H4. Here, we show that H3 and H4 deacetylation bears no relation to chromatin condensation, and present new ultrastructural and topological observations ...
D'Arrigo C +6 more
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2005
Abstract In the first chapter, we described the classical double-helical structure of DNA, and the local alterations of that structure that can occur as a consequence of specific nucleotide sequences. We hope you now have a good feel for these concepts, and we will move on to the main subject of this book, the supercoiling of DNA, a ...
Andrew D Bates, Anthony Maxwell
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Abstract In the first chapter, we described the classical double-helical structure of DNA, and the local alterations of that structure that can occur as a consequence of specific nucleotide sequences. We hope you now have a good feel for these concepts, and we will move on to the main subject of this book, the supercoiling of DNA, a ...
Andrew D Bates, Anthony Maxwell
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Statistical mechanics of supercoiled DNA
Physical Review E, 1995The conformation of long supercoiled DNA loops under near physiological conditions has been the subject of a long series of laboratory and Monte Carlo experiments, and impressive agreement between theory and experiment has been achieved [1–2]. A closed unnicked DNA loop has fixed linking number: this constraint leads to a competition between twisting ...
, Marko, , Siggia
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Supercoiled DNA: Hydrodynamic model
Journal of Theoretical Biology, 1974Two and three parameter theories have been introduced to describe the sedimentation behavior of the twisted DNA molecule compared to nontwisted DNA molecule. In the first model, the sedimentation equations have been developed using two parameters, namely, the excluded volume and the chain stiffness.
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Computer simulation of DNA supercoiling
Journal of Molecular Biology, 1991We treat supercoiled DNA within a wormlike model with excluded volume. A modified Monte Carlo approach has been used, which allowed computer statistical-mechanical simulations of moderately and highly supercoiled DNA molecules. Even highly supercoiled molecules do not have a regular shape, though with an increase in writhing the chains look more and ...
K V, Klenin +4 more
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Supercoil-Accelerated DNA Threading Intercalation
Biochemistry, 2009The effect of DNA supercoiling on a sterically very demanding threading intercalation process is investigated here. We find that the threading rate of a dimeric ruthenium complex into a negatively supercoiled plasmid at low binding density is 2 orders of magnitude higher than into the cleaved linear form.
Pär, Nordell +2 more
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Fluctuations and Supercoiling of DNA
Science, 1994Frequently, DNA in vivo is organized into loops that are partially underwound and consequently form interwound helical supercoils. Methods from polymer statistical mechanics are used to show how the competition between entropy (thermal fluctuations) and elastic energy determines supercoil radius and pitch, in good agreement with recent experiments and ...
J F, Marko, E D, Siggia
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