Results 21 to 30 of about 3,135 (178)
PLoS Genetics, 2012 Gyrase catalyzes negative supercoiling of DNA in an ATP-dependent reaction that helps condense bacterial chromosomes into a compact interwound "nucleoid." The supercoil density (σ) of prokaryotic DNA occurs in two forms. Diffusible supercoil density (σ(D)
Nikolay Rovinskiy +4 more
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Microorganisms, 2019 Prokaryotes have an essential gene—gyrase—that catalyzes negative supercoiling of plasmid and chromosomal DNA. Negative supercoils influence DNA replication, transcription, homologous recombination, site-specific recombination, genetic ...
Nikolay S. Rovinskiy +3 more
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mBio, 2015 Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome.
Xuejiao Jiang +4 more
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Frontiers in Pharmacology, 2022 Introduction: CD26/dipeptidyl peptidase IV (DPP4) is a cell-surface glycoprotein present on most epithelial cells that modulates the local response to external signals. We have previously shown that the dietary flavone apigenin (4′,5,7-trihydroxyflavone)
Julia E. Fux +4 more
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Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase
Molecules, 2017 Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after ...
Dawei Li +5 more
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Expression of RecF and GyrB Genes in a Low Ciprofloxacin-resistant Escherichia coli Mutant [PDF]
Biological Journal of Microorganism, 2018 Introduction: Replication and recombination are two fundamental cellular processes. GyrB and RecF are two proteins that are involved in these processes, respectively. GyrB is a subunit of DNA gyrase, the enzyme maintains negative supercoil in genomic DNA.
Marzieh sadat moosavi +2 more
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Behavior of Supercoiled DNA [PDF]
Biophysical Journal, 1998 We study DNA supercoiling in a quantitative fashion by micromanipulating single linear DNA molecules with a magnetic field gradient. By anchoring one end of the DNA to multiple sites on a magnetic bead and the other end to multiple sites on a glass surface, we were able to exert torsional control on the DNA. A rotating magnetic field was used to induce
Strick, T.R. +3 more
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Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.
PLoS ONE, 2010 BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts +4 more
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Dimensions of plectonemically supercoiled DNA [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2002 With a view to determine the configuration and regularity of plectonemically supercoiled DNA, we have measured the small angle neutron scattering from pUC18 plasmid in saline solutions. Furthermore, we have derived the mathematical expression for the single chain scattering function (form factor) of a superhelical structure, including the longitudinal ...
Zakharova, Svetlana S. +5 more
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Distribution bias and biochemical characterization of TOP1MT single nucleotide variants
Scientific Reports, 2017 Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase encoded in the nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT possesses two high frequency single nucleotide variants (SNVs), rs11544484 (V256I ...
Hongliang Zhang +4 more
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