Results 31 to 40 of about 3,135 (178)
Journal of Cell Science, 1975 ABSTRACT The three-dimensional structure of a double-stranded DNA molecule may be described by distinguishing the helical turns of the DNA duplex from any superhelical turns that might be superimposed upon the duplex turns. There are characteristic changes in the hydrodynamic properties of superhelical DNA molecules when they interact ...
Cook, P, Brazell, I
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Molecular Oncology, 2019 Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2).
Syed Moiz Ahmed, Peter Dröge
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The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling
Frontiers in Microbiology, 2017 The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins.
Adela G. de la Campa +5 more
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DNA supercoiling during transcription
Biophysical Reviews, 2016 The twin-supercoiled-domain model describes how transcription can drive DNA supercoiling, and how DNA supercoiling, in turn plays an important role in regulating gene transcription. In vivo and in vitro experiments have disclosed many details of the complex interactions in this relationship, and recently new insights have been gained with the help of ...
Jie Ma, Michelle D. Wang
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Advanced Science, Volume 13, Issue 4, 19 January 2026.Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian +3 more
wiley +1 more source
Molecules, 2014 A set of solanidine analogs with antiproliferative properties were recently synthetized from pregnadienolone acetate, which occurs in Nature. The aim of the present study was an in vitro characterization of their antiproliferative action and an ...
István Zupkó +10 more
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Iron Sulfides Produced by Thermococcales: An Iron Detoxification Mechanism
Environmental Microbiology, Volume 28, Issue 1, January 2026.Thermococcales, archaea from hydrothermal vents, promote iron sulfide precipitation, enabling survival in iron‐rich environments. Some cells become encrusted in pyrite and do not survive mineralization, while surviving cells activate metal detoxification genes. This biomineralization process allows the population to withstand toxic iron concentrations,
T. Mariotte +4 more
wiley +1 more source
PLoS ONE, 2019 The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However,
Syed Moiz Ahmed +12 more
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Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs
Genes to Cells, Volume 31, Issue 1, January 2026.Topoisomerase II (TOP2) relieving DNA torsional stress is trapped by TOP2 poisons, such as etoposide, inducing DNA double‐strand breaks (DSBs) bearing TOP2–DNA–protein crosslinks (TOP2–DPCs), which must be removed before DSB repair. This review summarizes the TOP2–DPC resolution processes mediated by multiple pathways, including proteolysis and ...
Ryo Sakasai, Kuniyoshi Iwabuchi
wiley +1 more source
BMC Genomics, 2002 Background Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share 80% amino acid identities.
Kohlhagen Glenda +6 more
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