Results 61 to 70 of about 3,135 (178)
Molecular Microbiology, Volume 123, Issue 6, Page 531-546, June 2025.Nucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Sara Moutacharrif +6 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 4, April 2025.A series of benzimidazolium chlorides and their 2‐mercapto were successfully synthesized and characterized. Cytotoxic activity assays revealed that certain synthesized compounds exhibited efficacy against cancer cell lines. To investigate the possible mechanism underlying their cytotoxic effects, the binding interactions of the three most active ...
Mohammad Mavvaji +5 more
wiley +1 more source
BioEssays, Volume 47, Issue 3, March 2025.Ion channel magnetic pharmacology. Mechanosensitive ion channels and calcium signaling might be regulated using moderate static uniform and gradient magnetic fields. It also appears possible to manipulate the activity of voltage‐gated channels and cytosolic Ca2⁺ levels with low‐frequency magnetic fields.
Vitalii Zablotskii +2 more
wiley +1 more source
Regulation of DNA Topology in Archaea: State of the Art and Perspectives
Molecular Microbiology, Volume 123, Issue 3, Page 245-264, March 2025.DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the current understanding of regulation of supercoiling by DNA topoisomerases in the third domain of life, the Archaea, with a particular focus on three key model ...
Paul Villain, Tamara Basta
wiley +1 more source
Physical models of bacterial chromosomes
Molecular Microbiology, Volume 123, Issue 2, Page 143-153, February 2025.Connecting experimental observations to biophysical models can give rise to new insights on bacterial chromosome organization. Simple polymer models explore how physical constraints affect bacterial chromosome organization; bottom‐up mechanistic models connect these constraints to their underlying causes; and data‐driven models are inferred directly ...
Janni Harju, Chase P. Broedersz
wiley +1 more source
Atomic description of the reciprocal action between supercoils and melting bubbles on linear DNA [PDF]
, 2023 Matthew Burman, Agnes Noy
openalex +1 more source
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils [PDF]
, 2023 Kristian Jeppsson +10 more
openalex +1 more source
Centromeric Nucleosomes Induce Positive DNA Supercoils [PDF]
, 2009 Takehito Furuyama, Steven Henikoff
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Control of bacterial DNA supercoiling [PDF]
Molecular Microbiology, 1992 SummaryTwo DNA topoisomerases control the level of negative supercoiling in bacterial cells. DNA gyrase introduces supercoils, and DNA topoisomerase I prevents super‐coiling from reaching unacceptably high levels. Perturbations of supercoiling are corrected by the substrate preferences of these topoisomerases with respect to DNA topology and by changes
openaire +2 more sources
Vaccinia virus DNA topoisomerase I preferentially removes positive supercoils from DNA [PDF]
, 1996 Maria-Elena Fernandez-Beros +1 more
openalex +1 more source