The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA. [PDF]
PLoS ONE, 2011 BACKGROUND: Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity.
Kathryn L Gilroy, Caroline A Austin
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MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
Biology Open, 2012 Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions ...
Ka Cheong Lee +10 more
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On the viability of
BMC Microbiology, 2012 Background Manipulations of the DNA double helix during replication, transcription and other nucleic acid processing cause a change of DNA topology, which results in torsional stress.
Stockum Anna +2 more
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Potential COX2 mediated Therapeutic effect of Ciprofloxacin [PDF]
Minia Journal of Medical Research, 2021 Fluoroquinolones (FQs) are broad-spectrum, synthetic antibiotics that inhibit bacterial DNA synthesis. FQs directly block DNA synthesis in the bacterial cell via inhibition the activity of two tetrameric, ATPdependent, homologous type II topoisomerase ...
Marwa Eisa +2 more
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eLife, 2022 Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH)2 domains, which include 3 AP lyase repair domains.
Amy Osterman, Alfonso Mondragón
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Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents
Pharmaceuticals, 2023 Topoisomerases are very important enzymes that regulate DNA topology and are vital for biological actions like DNA replication, transcription, and repair. The emergence and spread of cancer has been intimately associated with topoisomerase dysregulation.
Prasanna Anjaneyulu Yakkala +3 more
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SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
Frontiers in Molecular Biosciences, 2022 Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA.
Yilun Sun, John L. Nitiss, Yves Pommier
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Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II). [PDF]
PLoS ONE, 2015 Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement.
Bokun Cheng +4 more
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CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA. [PDF]
PLoS ONE, 2014 CFS-1686 (chemical name (E)-N-(2-(diethylamino)ethyl)-4-(2-(2-(5-nitrofuran-2-yl)vinyl)quinolin-4-ylamino)benzamide) inhibits cell proliferation and triggers late apoptosis in prostate cancer cell lines.
Ru-Wei Lin +11 more
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Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids [PDF]
, 2012 PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
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