Results 201 to 210 of about 17,370 (252)

MYC modulates TOP2A diffusion to promote substrate detection and activity. [PDF]

Nat Commun
Cameron DP, Jackson K, Loffreda A, Möller C, Kuzin V, Mazzocca M, Iliopoulou E, Kolbeinsdottir H, Paluda A, Pavlova E, Jagodic B, Lopez Duran BS, Lamour V, Westerlund F, Mazza D, Baranello L.   +15 more
europepmc   +1 more source

How Do Gepotidacin and Zoliflodacin Stabilize DNA-Cleavage Complexes with Bacterial Type IIA Topoisomerases? 2. A Single Moving Metal Mechanism. [PDF]

Int J Mol Sci
Nicholls RA, Morgan H, Warren AJ, Ward SE, Long F, Murshudov GN, Sutormin D, Bax BD.   +7 more
europepmc   +1 more source

Adding a twist to the loops: the role of DNA superhelicity in the organization of chromosomes by SMC protein complexes. [PDF]

Biochem Soc Trans
Valdés A, Haering CH.
europepmc   +1 more source

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE. [PDF]

PLoS Biol
Song PY, Tsai CE, Chen YC, Huang YW, Chen PP, Wang TH, Hu CY, Chen PY, Ku C, Hsia KC, Ting SY.   +10 more
europepmc   +1 more source

Real-time imaging of rotation during synthesis by the replisome. [PDF]

Sci Adv
Retzer TM, Rajappa LT, Takahashi M, Hamdan SM, Duderstadt KE.   +4 more
europepmc   +1 more source

Regulation of DNA Topology in Archaea: State of the Art and Perspectives. [PDF]

Mol Microbiol
Villain P, Basta T.
europepmc   +1 more source

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Type I DNA Topoisomerases

Journal of Medicinal Chemistry, 2017
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI, MARINELLO, JESSICA, CHILLEMI, GIOVANNI   +2 more
openaire   +4 more sources

A DNA topoisomerase type I from wheat embryo mitochondria

Plant Molecular Biology, 1986
In order to study DNA replication and expression in wheat mitochondria our laboratory has been seeking to develop a system that supports DNA synthesis and transcription, either in isolated mitochondria from wheat embryos or in a mitochondrial lysate from the same source deprived of endogenous DNA in vitro.
M, Echeverria, M T, Martin, B, Ricard, S, Litvak   +3 more
openaire   +2 more sources

Stimulation of type I DNA topoisomerase gene expression by pseudorabies virus

Archives of Virology, 1997
Previous results from our laboratory have demonstrated that type I DNA topoisomerase activity is required for the replication and gene expression of pseudorabies virus (PRV). In the present report, we further analyzed the expression of topoisomerase I in PRV-infected cells, and the western blot result showed that the expression of topoisomerase I was ...
M L, Wong, T Y, Ho, J H, Huang, C Y, Hsiang, T J, Chang   +4 more
openaire   +2 more sources

Type II DNA Topoisomerase from Saccharomyces cerevisiae Is a Stable Dimer

Biochemistry, 1997
Type II DNA topoisomerases function as homodimeric enzymes in transiently cleaving double-stranded DNA to catalyze unlinking and unknotting reactions. The dimeric enzyme creates a DNA double-strand break by forming a covalent attachment between an active site tyrosine from each monomer and a 5'-phosphate from each strand of DNA.
R B, Tennyson, J E, Lindsley
openaire   +2 more sources