Results 181 to 190 of about 9,967 (240)

Potential Biological Targets of Anticancer Metal-Based Drug Candidates: A Systematic Review. [PDF]

Drug Dev Res
Ferreira ALDS, Dantas BB, Souza-Ferrari J, Filho EBA.   +3 more
europepmc   +1 more source

Conformations of the three gates in Saccharomyces cerevisiae topoisomerase II and their response to DNA, nucleotide, and etoposide. [PDF]

J Biol Chem
Stelljes JT, Klostermeier D.
europepmc   +1 more source

TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction. [PDF]

Sci Adv
Terrón-Bautista J, Bejarano-Franco M, Del Mar Martínez-Sánchez M, López-Hernández L, Díaz-Maldonado H, Santiago-Gómez A, Kidane S, Jaguva Vasudevan AA, García-Domínguez M, Williams RS, Aguilera A, Millán-Zambrano G, Cortés-Ledesma F.   +12 more
europepmc   +1 more source

Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC). [PDF]

Oncol Res
Mestareehi A.
europepmc   +1 more source

Quick creation and mapping of EMS-induced maize kernel mutants identifies classical gene ZmBT1 and novel gene ZmTOP6A. [PDF]

Plant Genome
Dong H, Chen H, Jiang Y, Zhang J, Wang C, Sun Z, Su S, Li S, Liu H, Shan X, Yuan Y.   +10 more
europepmc   +1 more source

Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor. [PDF]

PLoS One
Kumar ARK, Shaji CS, Rajagopalan A, Bhattacharya S, Martínez-López W, Saraswathy R.   +5 more
europepmc   +1 more source

Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer. [PDF]

Commun Biol
Thapa N, Kim A, Patel P, Nguyen MQ, Lee E, Karki R.   +5 more
europepmc   +1 more source

Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase

Critical Reviews in Biochemistry and Molecular Biology, 2001
DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism.
Bakshi, RP, Galande, S, Muniyappa, K
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Type II DNA topoisomerases in trypanosomatid and apicomplexan parasites

Acta Tropica, 2022
Diseases caused by trypanosomatid parasites have no commercially available vaccines for human application. Treatment modalities completely rely on chemotherapeutics strategies that often exhibit clinical drawbacks, like host toxicity, side effects and treatment failure for drug resistance.
Somenath Roy Chowdhury, Arpita Bhoumik, Vivek Kumar Gupta, Hemanta K. Majumder   +3 more
openaire   +2 more sources