Results 201 to 210 of about 9,967 (240)
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Biochemical basis for the interactions of type I and type II topoisomerases with DNA
Pharmacology & Therapeutics, 1989DNA topoisomerases are complex and unique enzymes which alter the topological state of DNA without changing its chemical structure. Between the type I and II enzymes, topoisomerases carry out a multitude of reactions, including DNA binding, site specific DNA cleavage/religation, relaxation, catenation/decatenation, and knotting/unknotting of nucleic ...
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DNA Cleavage Mediated by Bacterial Type II Topoisomerases
The maintenance of DNA topology is critical for cellular processes. Topoisomerases are a class of enzymes found in eukaryotic and prokaryotic organisms that modulate the topology of DNA during replication and transcription. Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are essential for bacterial cell survival.Chelsea A, Mann, Neil, Osheroff
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BACTERIAL DIVERSITY BASED ON TYPE II DNA TOPOISOMERASE GENES
Annual Review of Genetics, 1996▪ Abstract  Type II DNA topoisomerases are essential and ubiquitous DNA metabolic enzymes that alter DNA topology. Eubacteria have two indispensable type II DNA topoisomerases, DNA gyrase encoded by gyrB and gyrA and topoisomerase IV encoded by parE and parC. These genes belong to a single family whose members span both eukaryotes and prokaryotes. The
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Simplification of DNA Topology Below Equilibrium Values by Type II Topoisomerases
Science, 1997Type II DNA topoisomerases catalyze the interconversion of DNA topoisomers by transporting one DNA segment through another. The steady-state fraction of knotted or catenated DNA molecules produced by prokaryotic and eukaryotic type II topoisomerases was found to be as much as 80 times lower than at thermodynamic equilibrium.
V V, Rybenkov +3 more
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Expression and cellular localization of Trypanosoma cruzi type II DNA topoisomerase
Molecular and Biochemical Parasitology, 1998Topoisomerases are enzymes that participate in many cellular functions involving topological manipulation of DNA strands. There are two types of topoisomerases in the cell: (a) type I topoisomerases; and (b) type II topoisomerases (topo II). Previously we have cloned and sequenced the gene encoding Trypanosoma cruzi topo II (TcTOP2).
S P, Fragoso +4 more
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DNA transport by a type II DNA topoisomerase: Evidence in favor of a two-gate mechanism
Cell, 1994DNA substrates in which a supercoiled DNA is singly linked to a nicked or relaxed DNA ring were used to analyze the transport of one DNA ring through another by yeast DNA topoisomerase II. The enzyme binds preferentially to the supercoiled DNA and promotes decatenation efficiently upon binding of a nonhydrolyzable ATP analog.
J, Roca, J C, Wang
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A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage
Biochemical and Biophysical Research Communications, 1989Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
J K, Juang +3 more
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Topology, Type II DNA Topoisomerases and DNA Replication in Prokaryotes and Eukaryotes
1983DNA replication raises several topological questions. i) How did the two parental strands uncoil in spite of the restriction imposed to their rotation either by DNA circularity or by the barriers which segregate the chromosome into topologically independent domains? ii) How is tangling of the two daughter duplexes avoided? Which mechanism generates the
Patrick Forterre +2 more
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DNA Recognition/Processing | DNA Topoisomerases: Type II
2021Esha D. Dalvie, Neil Osheroff
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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