Results 211 to 220 of about 16,951 (259)
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Type II DNA Topoisomerases as Antibacterial Targets
Current Pharmaceutical Design, 1996DNA topoisomerases are a class of ubiquitous enzymes that maintain the topological structures of DNA in both prokaryotic and eukaryotic organisms. The enzymes catalyze DNA topoisomerization reactions through a sequential DNA breaking passing-resealing process, and are the targets of many important therapeutic agents for the treatment of cancer and ...
L. L. Shen, D. T. W. Chu
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Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo
Mutation Research Letters, 1993Ciprofloxacin (CF), a fluoroquinolone widely used as a potent antimicrobial drug, was evaluated in vivo in mouse bone marrow cells for its ability to induce clastogenicity and DNA damage in terms of increased sister-chromatid exchange (SCE) frequencies.
A, Mukherjee, S, Sen, K, Agarwal
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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase
Biochemical Pharmacology, 2006Radicicol derivatives are currently investigated as promising antitumoral drugs because they inhibit the activity of the molecular chaperone heat shock protein (HSP90), causing the destabilization and eventual degradation of HSP90 client proteins that are often associated with tumor cells.
Gadelle, D. +2 more
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DNA crossovers and type II DNA topoisomerases: A thermodynamical study.
Journal of molecular biology, 1999We present a theoretical study of the interaction of tight DNA crossovers with eukaryotic type II DNA topoisomerases. A quantitative analysis of the role of the enzyme during anaphase first shows that a tight DNA crossover should be an intermediate of the strand-passage reaction.
J L, Sikorav +3 more
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Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II
Bioorganic & Medicinal Chemistry Letters, 2005DNA topoisomerase (Topo) II is one of the target enzymes for chemotherapeutic drug development. Lanostane-type triterpenoids with various functional groups (-Cl, -Br, -OMe, -CHO, -CN, -COOH, and -COOMe) at C-2 were synthesized from 3-oxolanost-9(11)-en-24S,25-diol (9) isolated from Pinus luchuensis and their inhibitory effects on Topo II activity and ...
Shun-Ichi, Wada, Reiko, Tanaka
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Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase
Critical Reviews in Biochemistry and Molecular Biology, 2001DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism.
Bakshi, RP, Galande, S, Muniyappa, K
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BACTERIAL DIVERSITY BASED ON TYPE II DNA TOPOISOMERASE GENES
Annual Review of Genetics, 1996▪ Abstract Type II DNA topoisomerases are essential and ubiquitous DNA metabolic enzymes that alter DNA topology. Eubacteria have two indispensable type II DNA topoisomerases, DNA gyrase encoded by gyrB and gyrA and topoisomerase IV encoded by parE and parC. These genes belong to a single family whose members span both eukaryotes and prokaryotes. The
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Quinolones, 2-Pyridones and Resistant Type II DNA Topoisomerases
Current Pharmaceutical Design, 1997Abstract: DNA gyrase and topoisomerase IV, the bacterial type II DNA topoisomerases, are known to be the targets of fluoroquinolones. The l1uoroquinolones have rapid bactericidal action derived from their dual actions to inhibit the catalytic activity of the essential enzymes and to form a stable enzyme-DNA cleavable complex.
Linus. L. Shen +2 more
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A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage
Biochemical and Biophysical Research Communications, 1989Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
J K, Juang +3 more
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