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Phylogenomics of type II DNA topoisomerases
BioEssays, 2003AbstractType II DNA topoisomerases (Topo II) are essential enzymes implicated in key nuclear processes. The recent discovery of a novel kind of Topo II (DNA topoisomerase VI) in Archaea led to a division of these enzymes into two non‐homologous families, (Topo IIA and Topo IIB) and to the identification of the eukaryotic protein that initiates meiotic ...
Danièle, Gadelle +3 more
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The role of ATP in the reactions of type II DNA topoisomerases
Biochemical Society Transactions, 2010Type II DNA topoisomerases catalyse changes in DNA topology in reactions coupled to the hydrolysis of ATP. In the case of DNA gyrase, which can introduce supercoils into DNA, the requirement for free energy is clear. However, the non-supercoiling type II enzymes carry out reactions that are apparently energetically favourable, so their requirement for ...
Andrew D, Bates, Anthony, Maxwell
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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
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Type II DNA Topoisomerases as Antibacterial Targets
Current Pharmaceutical Design, 1996DNA topoisomerases are a class of ubiquitous enzymes that maintain the topological structures of DNA in both prokaryotic and eukaryotic organisms. The enzymes catalyze DNA topoisomerization reactions through a sequential DNA breaking passing-resealing process, and are the targets of many important therapeutic agents for the treatment of cancer and ...
L. L. Shen, D. T. W. Chu
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DNA crossovers and type II DNA topoisomerases: A thermodynamical study.
Journal of molecular biology, 1999We present a theoretical study of the interaction of tight DNA crossovers with eukaryotic type II DNA topoisomerases. A quantitative analysis of the role of the enzyme during anaphase first shows that a tight DNA crossover should be an intermediate of the strand-passage reaction.
J L, Sikorav +3 more
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Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo
Mutation Research Letters, 1993Ciprofloxacin (CF), a fluoroquinolone widely used as a potent antimicrobial drug, was evaluated in vivo in mouse bone marrow cells for its ability to induce clastogenicity and DNA damage in terms of increased sister-chromatid exchange (SCE) frequencies.
A, Mukherjee, S, Sen, K, Agarwal
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Computational Analysis of the Chiral Action of Type II DNA Topoisomerases
Journal of Molecular Biology, 2002It was found recently that bacterial type II DNA topoisomerase, topo IV, is much more efficient in relaxing (+) DNA supercoiling than (-) supercoiling. This means that the DNA-enzyme complex is chiral. This chirality can appear upon binding the first segment that participates in the strand passing reaction (G segment) or only after the second segment ...
Konstantin, Klenin +2 more
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Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II
Bioorganic & Medicinal Chemistry Letters, 2005DNA topoisomerase (Topo) II is one of the target enzymes for chemotherapeutic drug development. Lanostane-type triterpenoids with various functional groups (-Cl, -Br, -OMe, -CHO, -CN, -COOH, and -COOMe) at C-2 were synthesized from 3-oxolanost-9(11)-en-24S,25-diol (9) isolated from Pinus luchuensis and their inhibitory effects on Topo II activity and ...
Shun-Ichi, Wada, Reiko, Tanaka
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Single-molecule analysis of DNA uncoiling by a type II topoisomerase
Nature, 2000Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA.
T R, Strick, V, Croquette, D, Bensimon
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The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase
Biochemical Pharmacology, 2006Radicicol derivatives are currently investigated as promising antitumoral drugs because they inhibit the activity of the molecular chaperone heat shock protein (HSP90), causing the destabilization and eventual degradation of HSP90 client proteins that are often associated with tumor cells.
Gadelle, D. +2 more
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