Results 121 to 130 of about 124,583 (279)

Variable DNA topology is an epigenetic generator of physiological heterogeneity in bacterial populations. [PDF]

Mol Microbiol, 2023
Dorman CJ.
europepmc   +1 more source

DNA topology as a factor affecting transcription in bacteria [PDF]

DNA topology plays a key role in regulation of gene expression by affecting interactions between DNA and RNA polymerase and other regulatory proteins. In this work, I review the process of transcription and selected mechanisms of its regulation, focusing
Hladíková, Kristýna
core   +1 more source

Repair of oxidatively-induced clustered DNA lesions, after exposure of human cancer cells to ionizing radiation

, 2017
In the present thesis, the induction and repair of complex DNA lesions, double strand breaks (DSBs) of high complexity accompanied by oxidatively-induced base lesions in their close vicinity were studied after exposure to ionizing radiation (IR) of ...
Νικητάκη, Ζαχαρένια, Νικητάκη, Ζαχαρένια, Nikitaki, Zacharenia   +2 more
core   +1 more source

Changes in the Topology of DNA Replication Intermediates: In vivo vs In vitro [PDF]

, 2021
Most of the methods used to analyze DNA, including electrophoresis, electron microscopy or atomic force microscopy, involve de-proteinization, and it is well known that the removal of proteins affects DNA topology.
Schvartzman, Jorge Bernardo, Fernández Nestosa, María José, Martínez, Víctor, Hernández, Pablo, Krimer, Dora B.   +4 more
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis

, 2012
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide ...
Summers, Emma Louise
core  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling

Nature Communications
RNA polymerase (RNAP) must unwind duplex DNA prior to transcription initiation. In bacteria, unwinding starts at a DNA motif called the promoter −10 element. Specifically, non-template strand bases interact with RNAP to trigger the process.
David Forrest, Emily A. Warman, David C. Grainger   +2 more
doaj   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria. [PDF]

Nucleic Acids Res, 2022
Menger KE, Chapman J, Chapman J, Díaz-Maldonado H, Khazeem MM, Deen D, Erdinc D, Casement JW, Di Leo V, Pyle A, Rodríguez-Luis A, Cowell IG, Falkenberg M, Austin CA, Nicholls TJ.   +14 more
europepmc   +1 more source

Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage

, 2015
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values.
Fernàndez, Xavier, Rodríguez-Campos, Antonio, Martínez-García, Belén, Manichanh, Chaysavanh, Roca, Joaquim, Díaz-Ingelmo, Ofelia   +5 more
core   +1 more source