Results 11 to 20 of about 2,766,615 (303)
DNA topology and transcription. [PDF]
Nucleus, 2014 Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems.
Kouzine F, Levens D, Baranello L.
europepmc +5 more sources
The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. [PDF]
Biophys Rev, 2016 Topological properties of DNA influence its structure and biochemical interactions. Within the cell DNA topology is constantly in flux. Transcription and other essential processes including DNA replication and repair, alter the topology of the genome, while introducing additional complications associated with DNA knotting and catenation.
Seol Y, Neuman KC.
europepmc +9 more sources
Cell-free DNA topology depends on its subcellular and cellular origins in cancer [PDF]
JCI Insight, 2022 Cancer cells release large quantities of cell-free DNA (cfDNA) into the surrounding tissue and circulation. As cfDNA is a common source of biomarkers for liquid biopsy and has been implicated as a functional mediator for intercellular communication ...
Ethan Z. Malkin +8 more
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Topoisomerase 2β and DNA topology during B cell development [PDF]
Frontiers in Immunology, 2022 Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes ...
Olivier Papapietro +4 more
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Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. [PDF]
Sci Rep, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Gu M +5 more
europepmc +2 more sources
Innovative Tools for DNA Topology Probing in Human Cells Reveal a Build-Up of Positive Supercoils Following Replication Stress at Telomeres and at the FRA3B Fragile Site [PDF]
CellsLinear unconstrained DNA cannot harbor supercoils since these supercoils can diffuse and be eliminated by free rotation of the DNA strands at the end of the molecule.
Claire Ghilain +5 more
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Helical chirality: a link between local interactions and global topology in DNA. [PDF]
PLoS ONE, 2010 DNA supercoiling plays a major role in many cellular functions. The global DNA conformation is however intimately linked to local DNA-DNA interactions influencing both the physical properties and the biological functions of the supercoiled molecule ...
Youri Timsit, Péter Várnai
doaj +12 more sources
DNA Topology and the Initiation of Virus DNA Packaging. [PDF]
PLoS ONE, 2016 During progeny assembly, viruses selectively package virion genomes from a nucleic acid pool that includes host nucleic acids. For large dsDNA viruses, including tailed bacteriophages and herpesviruses, immature viral DNA is recognized and translocated ...
Choon Seok Oh +8 more
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Journal of Extracellular Vesicles, 2019 Extracellular vesicles have the capacity to transfer lipids, proteins, and nucleic acids between cells, thereby influencing the recipient cell’s phenotype.
Elisa Lázaro-Ibáñez +7 more
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Nucleosomal DNA has topological memory
Nature CommunicationsOne elusive aspect of the chromosome architecture is how it constrains the DNA topology. Nucleosomes stabilise negative DNA supercoils by restraining a DNA linking number difference (∆Lk) of about −1.26.
Joana Segura +5 more
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