Results 31 to 40 of about 230,805 (269)
“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process
Frontiers in Molecular Biosciences, 2020 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5′-phosphate, 3′-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Almudena Serrano-Benítez +4 more
doaj +1 more source
Tumor suppressor p53 binds with high affinity to CTG-CAG trinucleotide repeats and induces topological alterations in mismatched duplexes [PDF]
, 2005 DNA binding is central to the ability of p53 to function as a tumor suppressor. In line with the remarkable functional versatility of p53, which can act on DNA as a transcription, repair, recombination, replication, and chromatin accessibility factor ...
Ahn +73 more
core +1 more source
The core of a class of non-atomic games which arise in economic applications [PDF]
, 1999 We study the core of a non-atomic game v which is uniformly continuous with respect to the DNA-topology and continuous at the grand coalition. Such a game has a unique DNA-continuous extension on the space B 1 of ideal sets. We show that if the extension
Einy, Ezra +2 more
core +3 more sources
DNA Mechanics and Topology [PDF]
, 2018 We review the current understanding of the mechanics of DNA and DNA-protein complexes, from scales of base pairs up to whole chromosomes. Mechanics of the double helix as revealed by single-molecule experiments will be described, with an emphasis on the role of polymer statistical mechanics.
Sumitabha, Brahmachari, John F, Marko
openaire +2 more sources
Topological Behavior of Plasmid DNA [PDF]
Microbiology Spectrum, 2014 ABSTRACT The discovery of the B-form structure of DNA by Watson and Crick led to an explosion of research on nucleic acids in the fields of biochemistry, biophysics, and genetics. Powerful techniques were developed to reveal a myriad of different structural conformations that change B-DNA as it is transcribed, replicated, and ...
N Patrick, Higgins +1 more
openaire +2 more sources
Hsmar1 transposition is sensitive to the topology of the transposon donor and the target. [PDF]
PLoS ONE, 2013 Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism.
Corentin Claeys Bouuaert +1 more
doaj +1 more source
Detection of recombination in DNA multiple alignments with hidden markov models [PDF]
, 2001 CConventional phylogenetic tree estimation methods assume that all sites in a DNA multiple alignment have the same evolutionary history. This assumption is violated in data sets from certain bacteria and viruses due to recombination, a process that leads
Dempster A.P. +2 more
core +2 more sources
Nature Communications, 2023 Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA ...
Qin Li +7 more
doaj +1 more source
Structural basis for allosteric regulation of Human Topoisomerase IIα
Nature Communications, 2021 Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing ...
Arnaud Vanden Broeck +5 more
doaj +1 more source
Evolutionary relationships in Panicoid grasses based on plastome phylogenomics (Panicoideae; Poaceae) [PDF]
, 2016 Background: Panicoideae are the second largest subfamily in Poaceae (grass family), with 212 genera and approximately 3316 species. Previous studies have begun to reveal relationships within the subfamily, but largely lack resolution and/or robust ...
Burke, Sean V. +9 more
core +2 more sources