Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]
Cell Reports, 2015 Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Alexander Harms +8 more
doaj +2 more sources
Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner [PDF]
Genome BiologyBackground Regulation of the target DNA cleavage activity of CRISPR/Cas has naturally evolved in a few bacteria or bacteriophages but is lacking in higher species.
Yuxuan Zhang +5 more
doaj +2 more sources
Editorial: Chromosome architecture and DNA topology in prokaryotes [PDF]
Frontiers in Microbiology, 2023 Tamara Basta +2 more
doaj +2 more sources
Rational design of topology-defined DNA nanoframeworks for antigen delivery and cross-presentation [PDF]
Journal of NanobiotechnologyDNA nanoframeworks (DNFs) provide structurally programmable platforms for antigen delivery, yet how framework topology influences antigen cross-presentation remains unclear.
Ying Cao +8 more
doaj +2 more sources
Regulation of DNA Topology in Archaea: State of the Art and Perspectives [PDF]
Molecular MicrobiologyTamara Basta
exaly +2 more sources
A review on nonlinear DNA physics [PDF]
Royal Society Open Science, 2020 The study and the investigation of structural and dynamical properties of complex systems have attracted considerable interest among scientists in general and physicists and biologists in particular.
Dalibor Chevizovich +4 more
doaj +1 more source
The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a [PDF]
Genes, 2019 Mark Szczelkun +2 more
exaly +2 more sources
Data of transcriptional effects of the merbarone-mediated inhibition of TOP2
Data in Brief, 2022 Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves +6 more
doaj +1 more source
Distinguishing regional from within-codon rate heterogeneity in DNA sequence alignments [PDF]
, 2009 We present an improved phylogenetic factorial hidden Markov model (FHMM) for detecting two types of mosaic structures in DNA sequence alignments, related to (1) recombination and (2) rate heterogeneity.
Husmeier, D. +4 more
core +5 more sources
Topogami: Topologically Linked DNA Origami [PDF]
ACS Nanoscience Au, 2021 DNA origami is a widely used DNA nanotechnology that allows construction of two-dimensional and three-dimensional nanometric shapes. The designability and rigidity of DNA origami make it an ideal material for construction of topologically linked molecules such as catenanes, which are attractive for their potential as motors and molecular machines ...
Yusuke Sakai +4 more
openaire +3 more sources