Results 31 to 40 of about 1,893,090 (266)
Tuning the topology of a two-dimensional catenated DNA network
Physical Review Research, 2023 Molecular topology of polymers plays a key role in determining their physical properties. We studied herein the topological effects on the static and dynamic properties of a 2D catenated network of DNA rings called a kinetoplast. Restriction enzymes that
Indresh Yadav +2 more
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Topological Behavior of Plasmid DNA [PDF]
Microbiology Spectrum, 2014 ABSTRACT The discovery of the B-form structure of DNA by Watson and Crick led to an explosion of research on nucleic acids in the fields of biochemistry, biophysics, and genetics. Powerful techniques were developed to reveal a myriad of different structural conformations that change B-DNA as it is transcribed, replicated, and ...
N Patrick, Higgins +1 more
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Hittite Journal of Science and Engineering, 2019 I n this study novel triplex forming DNA probes have been designed in order to detect Ag+ ion in low concentrations. The use of triplex forming oligonucleotides is a convenient in applications of sensing biomolecules due to their sequence specificity and
Osman Doluca
doaj +1 more source
“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process
Frontiers in Molecular Biosciences, 2020 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5′-phosphate, 3′-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Almudena Serrano-Benítez +4 more
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Topological entropy of DNA sequences [PDF]
Bioinformatics, 2011 Abstract Motivation: Topological entropy has been one of the most difficult to implement of all the entropy-theoretic notions. This is primarily due to finite sample effects and high-dimensionality problems. In particular, topological entropy has been implemented in previous literature to conclude that entropy of exons is higher than of ...
openaire +3 more sources
Hsmar1 transposition is sensitive to the topology of the transposon donor and the target. [PDF]
PLoS ONE, 2013 Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism.
Corentin Claeys Bouuaert +1 more
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Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases [PDF]
, 2010 ype II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage complex with a gate-DNA duplex that allows transport of a ...
Laponogov, I +27 more
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Nature Communications, 2023 Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA ...
Qin Li +7 more
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Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. [PDF]
Sci Rep, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Gu M +5 more
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Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]
, 2006 Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM +11 more
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