Results 11 to 20 of about 2,257,590 (274)
DNA-Topology Simplification by Topoisomerases [PDF]
Molecules, 2021 The topological properties of DNA molecules, supercoiling, knotting, and catenation, are intimately connected with essential biological processes, such as gene expression, replication, recombination, and chromosome segregation. Non-trivial DNA topologies
Andreas Hanke +2 more
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DNA Topology and the Initiation of Virus DNA Packaging. [PDF]
PLoS ONE, 2016 During progeny assembly, viruses selectively package virion genomes from a nucleic acid pool that includes host nucleic acids. For large dsDNA viruses, including tailed bacteriophages and herpesviruses, immature viral DNA is recognized and translocated ...
Choon Seok Oh +8 more
doaj +5 more sources
The Dynamic Interplay Between DNA Topoisomerases and DNA Topology [PDF]
Biophysical Reviews, 2016 Topological properties of DNA influence its structure and biochemical interactions. Within the cell DNA topology is constantly in flux. Transcription and other essential processes including DNA replication and repair, alter the topology of the genome, while introducing additional complications associated with DNA knotting and catenation.
Keir C. Neuman, Yeonee Seol
exaly +7 more sources
Controlling the topology of mammalian mitochondrial DNA [PDF]
Open Biology, 2021 The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes called nucleoids, and the density of mtDNA packaging affects mitochondrial gene ...
Katja E. Menger +3 more
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DNA topology and transcription [PDF]
Nucleus, 2014 Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems. In this superstructure, DNA is the subject of mechanical forces applied by variety of molecular motors.
Fedor, Kouzine +2 more
openaire +3 more sources
Applications of topology to DNA [PDF]
Banach Center Publications, 1998 0. Some preliminaries. Many biological processes affect topological properties of DNA. Duplex DNA consists of two backbone strands wound about each other in a righthanded helical fashion. Each strand consists of a sugar phosphate backbone with a nitrogenous base attached to each sugar. The four possible bases are adenine (A), guanine (G), cytosine (C),
De Sumners, Isabel Darcy
openaire +3 more sources
Journal of Extracellular Vesicles, 2019 Extracellular vesicles have the capacity to transfer lipids, proteins, and nucleic acids between cells, thereby influencing the recipient cell’s phenotype.
Elisa Lázaro-Ibáñez +7 more
doaj +2 more sources
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]
Sci Rep, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Miksovska, Jaroslava +5 more
core +2 more sources
Cell-free DNA topology depends on its subcellular and cellular origins in cancer [PDF]
JCI Insight, 2022 Cancer cells release large quantities of cell-free DNA (cfDNA) into the surrounding tissue and circulation. As cfDNA is a common source of biomarkers for liquid biopsy and has been implicated as a functional mediator for intercellular communication ...
Ethan Z. Malkin +8 more
doaj +2 more sources
Topoisomerase 2β and DNA topology during B cell development [PDF]
Frontiers in Immunology, 2022 Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes ...
Olivier Papapietro +4 more
doaj +2 more sources