Results 261 to 270 of about 2,766,615 (303)
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Topological DNA target size model
Radiation and Environmental Biophysics, 1990This study presents a model that explains the difference in radiosensitivity between dividing and resting mammalian non-lymphoid tissue cells (liver, kidney, respiratory tract, muscle cells, neurons), based on the topological organization of DNA. In dividing cells, the target for radiation might be identified in replicon clusters or domains (7 X 10(8 ...
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DNA framework-programmed cell capture via topology-engineered receptor-ligand interactions.
Journal of the American Chemical Society, 2019Receptor-ligand interactions (RLIs) that play pivotal roles in living organisms are often depicted with the classic keys-and-locks model. Nevertheless, RLIs on the cell surface are generally highly complex and nonlinear, partially due to the non ...
Min Li +11 more
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Topological Transformations of Synthetic DNA Knots
Biochemistry, 1995Two synthetic DNA molecules that can be knotted have been employed as substrates for E. coli DNA topoisomerases I and III. Both molecules contain 104 nucleotides, including sequences that can form two single-turn helical domains, connected by single-stranded oligo(dT) linkers in an X-Y-X'-Y' pairing motif. One of the knots can be ligated to form cyclic
S M, Du +3 more
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1991
Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria.
Patrick Forterre +3 more
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Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria.
Patrick Forterre +3 more
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DNA-Binding Proteins and DNA Topology
2007Introduction 279 Chromatin Proteins 280Archaeal Histones 280 Alba 284 Sul7 285 Sul10a 285Topoisomerases 286 Conclusions 286 References 287Extremophile microbiology has matured since the 1970s and 1980s when it was dominated by exploration of “ever-more-extreme” environments and classifying extremophiles, both as ...
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Changes in DNA topology during spermatogenesis
Chromosoma, 1986DNA topology in histone- and protamine-depleted nuclei (nucleoids) from somatic cells, sperm, and spermatogenic cells was studied to determine if the superhelical configuration of DNA looped domains is altered during spermatogenesis. The expansion and contraction of nucleoid DNA was measured with a fluorescence microscope following exposure of ...
M S, Risley, S, Einheber, D A, Bumcrot
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DNA Topology in Heterochromatin (a Hypothesis)
Journal of Theoretical Biology, 2000A hypothesis explaining the known heterochromatin features--a compact DNA packaging, transcriptional inactivity, propensity to aggregate (stickiness) and position effect variegation-is described. The hypothesis is based on the assumption that DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with ...
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Topologically Non-linked Circular Duplex DNA
Bulletin of Mathematical Biology, 2002The discovery of circular DNA, over 30 years ago, introduced an element of uneasiness in what had been, up to that point, the almost picture-perfect story of the elucidation of the molecular biology of heredity. If DNA indeed has the Watson-Crick right-handed helical secondary structure, then in circular DNA, thousands, or perhaps even millions of ...
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Physical Models for Exploring DNA Topology
Journal of Biomolecular Structure and Dynamics, 1988Two types of physical models have been developed for treating DNA molecules whose topology is of interest. The two model motifs combine jacks-and-straws molecular representations with flexible tubing in different proportions. Both motifs present a low-resolution construct of DNA that retains helix axes, strand individuality and the distinguishability ...
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