Results 241 to 250 of about 124,583 (279)

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]

Angew Chem Int Ed Engl
Qian Y, Ali MY, Karsisiotis AI, Dillon P, Dvorkin SA, McPherson PAC, Webba da Silva M.   +6 more
europepmc   +1 more source

On the optimization of copy number variations representation in pangenome graphs. [PDF]

Front Bioinform
Coggi M, Basile L, Branchini B, Amodeo G, Di Donato GW, Santambrogio MD.   +5 more
europepmc   +1 more source

Multiple Origins of a Sex Ratio Supergene in Formica Ants. [PDF]

Mol Biol Evol
Lagunas-Robles G, Purcell J, Shimota E, Brelsford A.   +3 more
europepmc   +1 more source

Gene Flow Complicates Phylogenetic Inference in an Archipelago Radiation. [PDF]

Syst Biol
Gyllenhaal EF, Klicka LB, DeCicco LH, Weeks BC, Moyle RG, Andersen MJ.   +5 more
europepmc   +1 more source

Extrachromosomal DNA in Solid Tumors-Landscape, Immune Effects, and Resistance to Targeted Therapy. [PDF]

Oncol Res
Badran O, Attarya S.
europepmc   +1 more source

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On proteins, DNA and topology

Trends in Biotechnology, 2002
In living cells, genomic DNA is organized into multiple topological domains that restrict the rotation of the double helix and cause DNA supercoiling. DNA topology is important for the intranuclear DNA packaging and plays a role in the regulation of gene expression.
exaly   +2 more sources

Topologically‐Interlocked Minicircles as Probes of DNA Topology and DNA‐Protein Interactions

Chemistry – A European Journal, 2022
AbstractDNA minicircles exist in biological contexts, such as kinetoplast DNA, and are promising components for creating functional nanodevices. They have been used to mimic the topological features of nucleosomal DNA and to probe DNA‐protein interactions such as HIV‐1 and PFV integrases, and DNA gyrase.
Arivazhagan Rajendran, Kirankumar Krishnamurthy, Seojeong Park, Eiji Nakata, Youngjoo Kwon, Takashi Morii   +5 more
openaire   +3 more sources

Energetics of twisted DNA topologies

Biophysical Journal, 2021
Our goal is to review the main theoretical models used to calculate free energy changes associated with common, torsion-induced conformational changes in DNA and provide the resulting equations hoping to facilitate quantitative analysis of both in vitro and in vivo studies.
Wenxuan, Xu, David, Dunlap, Laura, Finzi
openaire   +2 more sources

DNA topology

Choice Reviews Online, 2005
Abstract DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.
Andrew D Bates, Anthony Maxwell
openaire   +2 more sources