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Advancing protein engineering via organic chemistry. [PDF]
Commun ChemNithun RV, Singh M, Baransi A, Jbara M.
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Topologically‐Interlocked Minicircles as Probes of DNA Topology and DNA‐Protein Interactions
Chemistry – A European Journal, 2022AbstractDNA minicircles exist in biological contexts, such as kinetoplast DNA, and are promising components for creating functional nanodevices. They have been used to mimic the topological features of nucleosomal DNA and to probe DNA‐protein interactions such as HIV‐1 and PFV integrases, and DNA gyrase.
Arivazhagan Rajendran +5 more
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Choice Reviews Online, 2005
Abstract DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.
Andrew D Bates, Anthony Maxwell
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Abstract DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.
Andrew D Bates, Anthony Maxwell
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Energetics of twisted DNA topologies
Biophysical Journal, 2021Our goal is to review the main theoretical models used to calculate free energy changes associated with common, torsion-induced conformational changes in DNA and provide the resulting equations hoping to facilitate quantitative analysis of both in vitro and in vivo studies.
Wenxuan, Xu, David, Dunlap, Laura, Finzi
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Interlocked DNA topologies for nanotechnology
Current Opinion in Biotechnology, 2017Interlocked molecular architectures are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. The use of DNA for constructing these interlocked structures has increased significantly within the current decade.
Valero Moreno, Julian +2 more
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Expression of transfected DNA depends on DNA topology
Cell, 1986Supercoiled DNAs, especially those containing enhancers, yield markedly higher levels of expression than linearized DNA when transfected into CV-1 cells or L cells. Different templates, linear or supercoiled, enhancer-containing or not, saturate for expression at 2 micrograms DNA per dish, suggesting that one role for enhancers and supercoiling is to ...
H, Weintraub, P F, Cheng, K, Conrad
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Topology-dependent DNA binding
2023ABSTRACTDNA stores our genetic information and is ubiquitous in biological and biotechnological applications, where it interacts with binding partners ranging from small molecules to large macromolecular complexes. Binding is modulated by mechanical strains in the molecule and, in turn, can change the local DNA structure.
Pauline J. Kolbeck +5 more
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Small DNA circles as probes of DNA topology
Biochemical Society Transactions, 2013Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA.
Andrew D, Bates +4 more
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