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Interlocked DNA topologies for nanotechnology
Current Opinion in Biotechnology, 2017Interlocked molecular architectures are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. The use of DNA for constructing these interlocked structures has increased significantly within the current decade.
Valero, J., Lohman, F., Famulok, M.
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Small DNA circles as probes of DNA topology
Biochemical Society Transactions, 2013Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA.
Andrew D, Bates +4 more
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Expression of transfected DNA depends on DNA topology
Cell, 1986Supercoiled DNAs, especially those containing enhancers, yield markedly higher levels of expression than linearized DNA when transfected into CV-1 cells or L cells. Different templates, linear or supercoiled, enhancer-containing or not, saturate for expression at 2 micrograms DNA per dish, suggesting that one role for enhancers and supercoiling is to ...
H, Weintraub, P F, Cheng, K, Conrad
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DNA Topology in Heterochromatin (a Hypothesis)
Journal of Theoretical Biology, 2000A hypothesis explaining the known heterochromatin features--a compact DNA packaging, transcriptional inactivity, propensity to aggregate (stickiness) and position effect variegation-is described. The hypothesis is based on the assumption that DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with ...
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2013
In this expository chapter we give an elementary introduction to DNA and to proteins that can knot and link circular DNA, with a special focus on recombination. We also describe the Ernst and Sumners tangle model of the action of proteins on circular DNA.
Isabel K. Darcy +2 more
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In this expository chapter we give an elementary introduction to DNA and to proteins that can knot and link circular DNA, with a special focus on recombination. We also describe the Ernst and Sumners tangle model of the action of proteins on circular DNA.
Isabel K. Darcy +2 more
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2018
DNA holds the instructions for an organism’s development, reproduction, and, ultimately, death. It encodes much of the information a cell needs to survive and reproduce. It is important for inheritance and coding for proteins, and contains the genetic instruction guide for life and its processes.
Garrett Jones, Candice Reneé Price
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DNA holds the instructions for an organism’s development, reproduction, and, ultimately, death. It encodes much of the information a cell needs to survive and reproduce. It is important for inheritance and coding for proteins, and contains the genetic instruction guide for life and its processes.
Garrett Jones, Candice Reneé Price
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1991
Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria.
Patrick Forterre +3 more
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Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria.
Patrick Forterre +3 more
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DNA topology in a chromatin model system
Cell Biophysics, 1986The synthetic copolypeptide (Lys33, Leu67)100-Orn20, modeled on some general features of the histone sequences, has been found to supercoil the DNA double helix, wrapping it into a micelle, as a result of cohesive interactions between the polypeptide hydrophobic moieties.
CALASCIBETTA, Franco Giuseppe +4 more
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DNA-Binding Proteins and DNA Topology
2007Introduction 279 Chromatin Proteins 280Archaeal Histones 280 Alba 284 Sul7 285 Sul10a 285Topoisomerases 286 Conclusions 286 References 287Extremophile microbiology has matured since the 1970s and 1980s when it was dominated by exploration of “ever-more-extreme” environments and classifying extremophiles, both as ...
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