Results 41 to 50 of about 2,766,615 (303)
DNA Topology: Dynamic DNA Looping [PDF]
Current Biology, 2006 The DNA in repressive loops is often tightly bent. DNA flexibility imposes significant constraints on their topology suggesting that they may exist as perturbations in plectonemic DNA.
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Mutation of DNA and RNA sequences through the application of topological spaces
AIMS Mathematics, 2023 Topology is branch of modern mathematics that plays an important role in applications of biology. The aim of this paper is to study DNA sequence mutations using multisets, relations, metric functions, topology and association indices.
A. A. El-Atik +5 more
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Hittite Journal of Science and Engineering, 2019 I n this study novel triplex forming DNA probes have been designed in order to detect Ag+ ion in low concentrations. The use of triplex forming oligonucleotides is a convenient in applications of sensing biomolecules due to their sequence specificity and
Osman Doluca
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“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process
Frontiers in Molecular Biosciences, 2020 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5′-phosphate, 3′-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Almudena Serrano-Benítez +4 more
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An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
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Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. [PDF]
, 2013 Deregulation of mini-chromosome maintenance (MCM) proteins is associated with genomic instability and cancer. MCM complexes are recruited to replication origins for genome duplication.
Brewster, Aaron +7 more
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DNA Mechanics and Topology [PDF]
, 2018 We review the current understanding of the mechanics of DNA and DNA-protein complexes, from scales of base pairs up to whole chromosomes. Mechanics of the double helix as revealed by single-molecule experiments will be described, with an emphasis on the role of polymer statistical mechanics.
Sumitabha, Brahmachari, John F, Marko
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Nature Communications, 2023 Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA ...
Qin Li +7 more
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Topological Behavior of Plasmid DNA [PDF]
Microbiology Spectrum, 2014 ABSTRACT The discovery of the B-form structure of DNA by Watson and Crick led to an explosion of research on nucleic acids in the fields of biochemistry, biophysics, and genetics. Powerful techniques were developed to reveal a myriad of different structural conformations that change B-DNA as it is transcribed, replicated, and ...
N Patrick, Higgins +1 more
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Hsmar1 transposition is sensitive to the topology of the transposon donor and the target. [PDF]
PLoS ONE, 2013 Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism.
Corentin Claeys Bouuaert +1 more
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