Results 61 to 70 of about 2,766,615 (303)

Tangle analysis of difference topology experiments: applications to a Mu protein-DNA complex

, 2007
We develop topological methods for analyzing difference topology experiments involving 3-string tangles. Difference topology is a novel technique used to unveil the structure of stable protein-DNA complexes involving two or more DNA segments.
Arsuaga, Bauer, Chaconas, Hoess, Isabel Darcy, Jayaram, John Luecke, Kim, Mariel Vazquez, Saka, Scharlemann, Scharlemann, Stark, Sumners, Sumners, Wang, Wasserman, Watson, Yin, Zheng   +19 more
core   +1 more source

Methods and compositions for stimulating T-lymphocytes [PDF]

, 2003
Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A., Ioannides, Constantin G., Ioannides, Maria G.   +2 more
core   +1 more source

DNA topology influences molecular machine lifetime in human serum

Nanoscale, 2015
Lifetimes and operational performance were investigated for a DNA nanomachine and linear probe in human serum and blood to elucidate design principles for future biomedical applications of DNA-based devices.
Sara Goltry, Natalya Hallstrom, Tyler J. W. Clark, W. Kuang, Jeunghoon Lee, C. Jorcyk, W. B. Knowlton, B. Yurke, W. Hughes, E. Graugnard   +9 more
semanticscholar   +1 more source

DNA topology and topoisomerases [PDF]

Biochemistry and Molecular Biology Education, 2008
AbstractDNA is essentially an extremely long double‐stranded rope in which the two strands are wound about one another. As a result, topological properties of the genetic material, including DNA underwinding and overwinding, knotting, and tangling profoundly influence virtually every major nucleic acid process.
J. Deweese, M. Osheroff, N. Osheroff
semanticscholar   +3 more sources

Topological Process of Splitting DNA-Links

BIOMATH, 2022
A DNA replicon is modeled by a special type of 2-component link, called a DNA-link, in which two circles form a double helix around a trivial center core curve. The DNA replication process is semi-conservative, which is interpreted as a splitting process of the DNA-link.
Abdul Adheem Mohamad, Tsukasa Yashiro
openaire   +3 more sources

Topological data analysis of Escherichia coli O157:H7 and non-O157 survival in soils. [PDF]

, 2014
Shiga toxin-producing E. coli O157:H7 and non-O157 have been implicated in many foodborne illnesses caused by the consumption of contaminated fresh produce.
Crowley, David E, Ibekwe, Abasiofiok M, Johnson, Alexis M, Lum, Pek Y, Ma, Jincai, Petrossian, Tanya C, Yang, Ching-Hong   +6 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Capillarity Theory for the Fly-Casting Mechanism

, 2010
Biomolecular folding and function are often coupled. During molecular recognition events, one of the binding partners may transiently or partially unfold, allowing more rapid access to a binding site.
Chavez, Clementi, Clementi, Dunker, Dyson, E. Trizac, Finkelstein, Huang, Huang, Kubelka, Levy, Levy, Levy, Miyashita, Onuchic, Onuchic, P. G. Wolynes, Tompa, To  th-Petro  czy, Whitford, Wolynes, Wright, Wright, Y. Levy, Yang   +24 more
core   +2 more sources

Topology of Viral DNA

, 2010
Chromosome organization plays a key role in many biological processes. In viruses genome organization is essential for the packaging and releasing of the genome as well as for maintaining the stability of the viral capsid. This organization varies across different families and is highly dependent on the virus morphogenetic pathway (Casjens, 1997).
Arsuaga, Javier, Roca, Joaquim, Sumners, De Witt   +2 more
openaire   +2 more sources

DNA topology: Topoisomerases keep it simple [PDF]

Current Biology, 1997
The ability of type II DNA topoisomerases to perturb the equilibrium distributions of DNA topoisomers is a consequence of their ability to hydrolyse ATP. A sliding mechanism of topoisomerase action has been proposed to account for this phenomenon.
Bates, Andrew D, Maxwell, Anthony
openaire   +2 more sources