Results 1 to 10 of about 188,135 (149)

Lipid nanoparticle-encapsulated DNA vaccine induces balanced antibody and T-cell responses in pigs with maternally derived antibodies [PDF]

Journal of Virology
Maternally derived antibodies (MDAs) play a vital role in protecting neonates from infectious diseases, but their presence at the time of vaccination can interfere with vaccine-induced immune responses, thereby reducing vaccine effectiveness.
Danh C. Lai, The N. Nguyen, Giao P. Trinh, David Steffen, Hiep L. X. Vu   +4 more
doaj   +2 more sources

Polyethylenimine-Conjugated Au-NPs as an Efficient Vehicle for in vitro and in vivo DNA Vaccine Delivery [PDF]

International Journal of Nanomedicine
Aras Kartouzian,1 Alexandra Heiz,1 Kamyar Shameli,2,* Hassan Moeini3,* 1Catalysis Research Center, School of Natural Sciences, Technical University of Munich, Munich, Germany; 2Institute of Virology, School of Medicine, Technical University of ...
Kartouzian A, Heiz A, Shameli K, Moeini H   +3 more
doaj   +2 more sources

Induction of specific immune responses in inoculated mice by a eukaryotic plasmid expressing the G1 epitope of bovine ephemeral fever virus [PDF]

مجله بیوتکنولوژی کشاورزی, 2023
Objective Bovine ephemeral fever (BEF) is an arthropod-borne viral disease of cattle and water buffalos which causes considerable economic and commercial losses in the cattle industry.
Reza Pasandideh, Masoud Reza Seyfi Abad Shapouri, Mohammad Taghi Beygi Nassiri   +2 more
doaj   +1 more source

DNA Vaccines [PDF]

Critical Reviews™ in Immunology, 1998
DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
  +7 more sources

DNA vaccine containing Flagellin A gene induces significant immune responses against Helicobacter pylori infection: An in vivo study [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Helicobacter pylori is one of the most prevalent human infectious agents that is directly involved in various upper digestive tract diseases. Although antibiotics-based therapy and proton pump inhibitors eradicate the bacteria mostly, their
Hossein Ansari, Maryam Tahmasebi Birgani, Mahdi Bijanzadeh   +2 more
doaj   +1 more source

DNA Vaccines

Japanese Journal of Pharmacology, 2000
DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages
Y, Koide, T, Nagata, A, Yoshida, M, Uchijima   +3 more
  +8 more sources

DNA Vaccination

Current Protocols in Human Genetics, 2003
AbstractThis unit details some of the key methods for setting up and testing DNA vaccines in animal models. The basic procedures are discussed, as well as alternative methods that have been developed over the past several years. The gives step‐by‐step instructions for administering the DNA vaccine via intramuscular injection of the quadriceps muscle ...
Jeffrey B, Ulmer, Rino, Rappuoli
  +9 more sources

Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

Drug Delivery, 2021
We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective uptake ...
Yukinobu Kodama, Ayako Tokunaga, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Tomoaki Kurosaki, Tadahiro Nakamura, Koyo Nishida, Mikiro Nakashima, Mitsuru Hashida, Shigeru Kawakami, Hitoshi Sasaki   +11 more
doaj   +1 more source

DNA vaccines

Allergy, 1999
Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) virus are worldwide problems often leading to the development of chronic liver disease and hepatocellular carcinoma. Genetic immunizations with DNA encoding for structural and nonstructural proteins of HCV and HBV in experimental mice generate a broad base CD4+ and CD8+ cellular immune ...
H L, Spiegelberg, E, Raz
  +8 more sources

Research Note: The immune enhancement ability of inulin on ptfA gene DNA vaccine of avian Pasteurella multocida

Poultry Science, 2020
To evaluate the ability of inulin to enhance the immune response of a ptfA gene DNA vaccine for avian Pasteurella multocida, inulin was added as an adjuvant to the ptfA-DNA vaccine, obtaining an inulin-adjuvant DNA vaccine.
Q. Gong, Y.G. Peng, M.F. Niu, C.L. Qin
doaj   +1 more source