Results 21 to 30 of about 210,905 (300)

DNA-Encoded Fetal Liver Tyrosine Kinase 3 Ligand and Granulocyte Macrophage-Colony-Stimulating Factor Increase Dendritic Cell Recruitment to the Inoculation Site and Enhance Antigen-Specific CD4+ T Cell Responses Induced by DNA Vaccination of Outbred Animals [PDF]

, 2002
DNA-based immunization is a contemporary strategy for developing vaccines to prevent infectious diseases in animals and humans. Translating the efficacy of DNA immunization demonstrated in murine models to the animal species that represent the actual ...
Timothy V. Baszler, Baszler, Timothy V, Brown, Wendy C, Chris J. Howard, Jayne C. Hope, Wendy C. Brown, Lewin, Harris A., Waithaka Mwangi, Howard, Chris J, Palmer, Guy H, Patrick Caplazi, Abbott, Jeffrey, Mwangi, Waithaka, Hope, Jayne; id_orcid, Baszler, Tim V, Hope, Jayne C, Caplazi, Patrick, Harris A. Lewin, Guy H. Palmer, Jeffrey Abbott, Lewin, Harris A   +20 more
core   +1 more source

Immunotherapeutic effects of Mycobacterium tuberculosis rv3407 DNA vaccine in mice

Autoimmunity, 2018
Tuberculosis (TB) is a major global public health problem. Latent TB infection (LTBI) is a major source of active TB. New vaccines to treat LTBI are urgently demanded.
Yan Liang, Yajing Zhao, Xuejuan Bai, Li Xiao, Yourong Yang, Junxian Zhang, Lan Wang, Lei Cui, Tong Wang, Yingchang Shi, Weiguo Zhao, Xueqiong Wu   +11 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

Human Vaccines & Immunotherapeutics, 2017
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from
Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy   +7 more
doaj   +1 more source

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

Human Vaccines & Immunotherapeutics, 2017
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza.
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard   +5 more
doaj   +1 more source

Advancements in the development of nucleic acid vaccines for syphilis prevention and control

Human Vaccines & Immunotherapeutics, 2023
Syphilis, a chronic systemic sexually transmitted disease, is caused by the bacterium Treponema pallidum (T. pallidum). Currently, syphilis remains a widespread infectious disease with significant disease burden in many countries.
Sijia Li, Weiwei Li, Yinqi Jin, Bin Wu, Yimou Wu   +4 more
doaj   +1 more source

An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice

Human Vaccines & Immunotherapeutics, 2017
Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of ...
Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Insight into the current Toxoplasma gondii DNA vaccine: a review article

Expert Review of Vaccines, 2023
Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan   +8 more
doaj   +1 more source

The AhDREB transgene expression activates NtP5CS and NtSUSY, promoting osmotic adjustment in transgenic tobacco under salt stress

Czech Journal of Genetics and Plant Breeding
Soil salinity is a major environmental constraint that limits the growth and productivity of peanut (Arachis hypogaea L.), a legume adapted to mildly acidic soils but highly sensitive to saline-alkaline conditions. Dehydration-Responsive Element Binding (
Thuy Thi Xuan Vi, Dang Xuan Hoang, Tra Thi Nguyen, Ngoc Bich Pham, Quan Huu Nguyen, Mau Hoang Chu   +5 more
doaj   +1 more source

Design and Cloning of the Optimized L1 Gene from Human Papilloma virus 18 into the Expression Vector PcDNA3 and Evaluating its Expression in a Eukaryotic System

Iranian South Medical Journal, 2023
Background: Vaccines have played a special role in controlling and reducing mortality from infectious diseases. In this regard, DNA vaccines were developed to ease the production and reduce the risks of traditional vaccines.
Maryam Rahimpour, Sirous Naeimi, Azam Rahimpour, Fatemeh Farshadpour, Reza Taherkhani   +4 more
doaj