Results 21 to 30 of about 195,479 (250)

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

Human Vaccines & Immunotherapeutics, 2017
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza.
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard   +5 more
doaj   +1 more source

Advancements in the development of nucleic acid vaccines for syphilis prevention and control

Human Vaccines & Immunotherapeutics, 2023
Syphilis, a chronic systemic sexually transmitted disease, is caused by the bacterium Treponema pallidum (T. pallidum). Currently, syphilis remains a widespread infectious disease with significant disease burden in many countries.
Sijia Li, Weiwei Li, Yinqi Jin, Bin Wu, Yimou Wu   +4 more
doaj   +1 more source

An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice

Human Vaccines & Immunotherapeutics, 2017
Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of ...
Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Insight into the current Toxoplasma gondii DNA vaccine: a review article

Expert Review of Vaccines, 2023
Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan   +8 more
doaj   +1 more source

The AhDREB transgene expression activates NtP5CS and NtSUSY, promoting osmotic adjustment in transgenic tobacco under salt stress

Czech Journal of Genetics and Plant Breeding
Soil salinity is a major environmental constraint that limits the growth and productivity of peanut (Arachis hypogaea L.), a legume adapted to mildly acidic soils but highly sensitive to saline-alkaline conditions. Dehydration-Responsive Element Binding (
Thuy Thi Xuan Vi, Dang Xuan Hoang, Tra Thi Nguyen, Ngoc Bich Pham, Quan Huu Nguyen, Mau Hoang Chu   +5 more
doaj   +1 more source

Design and Cloning of the Optimized L1 Gene from Human Papilloma virus 18 into the Expression Vector PcDNA3 and Evaluating its Expression in a Eukaryotic System

Iranian South Medical Journal, 2023
Background: Vaccines have played a special role in controlling and reducing mortality from infectious diseases. In this regard, DNA vaccines were developed to ease the production and reduce the risks of traditional vaccines.
Maryam Rahimpour, Sirous Naeimi, Azam Rahimpour, Fatemeh Farshadpour, Reza Taherkhani   +4 more
doaj  

Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes

Vaccines, 2020
The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC-83 strain, was evaluated in mice.
Dylan M. Johnson, Kevin J. Sokoloski, Jenny D. Jokinen, Tia L. Pfeffer, Yong-Kyu Chu, Robert S. Adcock, Donghoon Chung, Irina Tretyakova, Peter Pushko, Igor S. Lukashevich   +9 more
doaj   +1 more source

Novel enzymatic DNA produced from a text file achieves comparable immune responses as plasmid vaccine

npj Vaccines
DNA vaccines have garnered considerable attention due to their recent success in humans for SARS-CoV-2 and immunotherapy for cancer. However, conventional methods for creating and manufacturing DNA vaccines at-scale are slow and rate-limiting for timely ...
James Fuller, Erik Kvam, Sandrine Creton, Courtney Hall, Nicholas J. Tursi, Kerry Blatney, Rebecca Ryan, Xavier Godron, David B. Weiner, Winston Timp, Weston Griffin, John Nelson, Deborah H. Fuller   +12 more
doaj   +1 more source

Dengue Vaccines: Current Status and Future Perspectives

APIK Journal of Internal Medicine
Dengue fever (DF), caused by the dengue virus (DENV), is a major public health problem worldwide, with approximately 390 million reported annual infections.
Vasantha Kamath, A. B. Aishwarya
doaj   +1 more source

Safety and long-term immunological effects of CryJ2-LAMP plasmid vaccine in Japanese red cedar atopic subjects: A phase I study

Human Vaccines & Immunotherapeutics, 2017
Japanese Red Cedar (JRC) pollen induced allergy affects one third of Japanese and the development of effective therapies remains an unachieved challenge.
Yan Su, Eliezer Romeu-Bonilla, Athanasia Anagnostou, David Fitz-Patrick, William Hearl, Teri Heiland   +5 more
doaj   +1 more source