Results 21 to 30 of about 1,964,734 (294)

DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System [PDF]

Iranian Journal of Immunology, 2020
Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB.
Ahmad Mobed
doaj   +1 more source

DNA-Encoded Fetal Liver Tyrosine Kinase 3 Ligand and Granulocyte Macrophage-Colony-Stimulating Factor Increase Dendritic Cell Recruitment to the Inoculation Site and Enhance Antigen-Specific CD4+ T Cell Responses Induced by DNA Vaccination of Outbred Animals [PDF]

, 2002
DNA-based immunization is a contemporary strategy for developing vaccines to prevent infectious diseases in animals and humans. Translating the efficacy of DNA immunization demonstrated in murine models to the animal species that represent the actual ...
Timothy V. Baszler, Baszler, Timothy V, Brown, Wendy C, Chris J. Howard, Jayne C. Hope, Wendy C. Brown, Lewin, Harris A., Waithaka Mwangi, Howard, Chris J, Palmer, Guy H, Patrick Caplazi, Abbott, Jeffrey, Mwangi, Waithaka, Hope, Jayne; id_orcid, Baszler, Tim V, Hope, Jayne C, Caplazi, Patrick, Harris A. Lewin, Guy H. Palmer, Jeffrey Abbott, Lewin, Harris A   +20 more
core   +1 more source

An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation [PDF]

, 2009
PhDSome recombinant bacterial strains have been shown to be very efficient in experimental therapies against cancer in rodent models. Amongst them is an E. coli that expresses the Listeriolysin-O protein (LLO) and a model tumour antigen ovalbumin (OVA)
Dai, Ming-Shen
core   +4 more sources

Immunotherapeutic effects of Mycobacterium tuberculosis rv3407 DNA vaccine in mice

Autoimmunity, 2018
Tuberculosis (TB) is a major global public health problem. Latent TB infection (LTBI) is a major source of active TB. New vaccines to treat LTBI are urgently demanded.
Yan Liang, Yajing Zhao, Xuejuan Bai, Li Xiao, Yourong Yang, Junxian Zhang, Lan Wang, Lei Cui, Tong Wang, Yingchang Shi, Weiguo Zhao, Xueqiong Wu   +11 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

Human Vaccines & Immunotherapeutics, 2017
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from
Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy   +7 more
doaj   +1 more source

Advancements in the development of nucleic acid vaccines for syphilis prevention and control

Human Vaccines & Immunotherapeutics, 2023
Syphilis, a chronic systemic sexually transmitted disease, is caused by the bacterium Treponema pallidum (T. pallidum). Currently, syphilis remains a widespread infectious disease with significant disease burden in many countries.
Sijia Li, Weiwei Li, Yinqi Jin, Bin Wu, Yimou Wu   +4 more
doaj   +1 more source

A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis [PDF]

, 2007
BACKGROUND: Mycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including primates. Humans are exposed through milk and from sources of environmental contamination.
Gilbert, SC, Richard Linedale, Hermon-Taylor John, Bull, TJ, Bull Tim J., Linedale Richard, Karim Sidi-Boumedine, Tim J Bull, John Hermon-Taylor, Linedale, R, Gilbert Sarah C., Gilbert, Sarah, Sidi-Boumedine Karim, Hermon-Taylor, J, Saranya Sridhar, Dierkes Nicola, Nicola Dierkes, Sridhar, S, Dierkes, N, Sidi-Boumedine, K, Sridhar Saranya, Sarah C Gilbert   +21 more
core   +1 more source

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

Human Vaccines & Immunotherapeutics, 2017
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza.
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard   +5 more
doaj   +1 more source

Insight into the current Toxoplasma gondii DNA vaccine: a review article

Expert Review of Vaccines, 2023
Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan   +8 more
doaj   +1 more source