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Japanese Journal of Pharmacology, 2000 DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages
Koide, Yukio +3 more
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The potential of plant-based vaccines [PDF]
Future Natural Products, 2022 Plants are cost-effective biological delivery carrier. Plant-based vaccines are more reliable due to the lack of human pathogen or endotoxin, and oncogenic DNA.
Mahdi Ghatreh Samani
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Current Biology, 1998 DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
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Expert Opinion on Emerging Drugs, 2003 There is increasing recognition that the unique antigenicities of the different stages of the Plasmodium spp. life cycle, the requirement for distinct immune mechanisms targeting these different stages, the immense allelic variation of parasites in the field, and the genetic heterogeneity of the target population pose enormous obstacles to the ...
Hedstrom, Richard C., Doolan, Denise L.
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Genome Medicine, 2021 Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li +17 more
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Have mRNA vaccines sentenced DNA vaccines to death?
Expert Review of Vaccines, 2023 Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
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Current Molecular Medicine, 2001 Within the last decade bacterial plasmids encoding foreign antigens have revolutionized vaccine design. Although no DNA vaccine has yet been approved for routine human or veterinary use, the potential of this vaccine modality has been demonstrated in experimental animal models.
Reyes-Sandoval, A, Ertl, H
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Nucleic Acid Vaccines: A Rising Antidote for the Future
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022 DNA vaccines, a type of nucleic acid vaccine, have emerged as one of the recent developments in immunology and recombinant DNA technology, offering great potential in terms of ease of manufacture, maintenance, and safety compared to conventional vaccines.
W. Roseybala Devi +5 more
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Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins
Frontiers in Immunology, 2021 IntroductionBorrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines. DNA tattoo vaccination with B.
Michelle J. Klouwens +10 more
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