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Current Molecular Medicine, 2001 Within the last decade bacterial plasmids encoding foreign antigens have revolutionized vaccine design. Although no DNA vaccine has yet been approved for routine human or veterinary use, the potential of this vaccine modality has been demonstrated in experimental animal models.
Reyes-Sandoval, A, Ertl, H
core +5 more sources
DNA Vaccines: Their Formulations, Engineering and Delivery [PDF]
VaccinesThe concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent many diseases ...
Michael Kozak, Jiafen Hu
doaj +2 more sources
Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses [PDF]
VirusesSingle-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses.
Peter Pushko +3 more
doaj +2 more sources
Needle-Free Devices and CpG-Adjuvanted DNA Improve Anti-HIV Antibody Responses of Both DNA and Modified Vaccinia Ankara-Vectored Candidate Vaccines [PDF]
Vaccines, 2023 The combination of mosaic Gag and CAP256 envelope in an HIV vaccine regimen comprising DNA prime and modified vaccinia Ankara (MVA) boost followed by protein boost has previously been shown to generate robust autologous Tier 2 neutralizing antibodies ...
Rosamund Chapman +5 more
doaj +2 more sources
Japanese Journal of Pharmacology, 2000 DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages
Koide, Yukio +3 more
+8 more sources
The potential of plant-based vaccines [PDF]
Future Natural Products, 2022 Plants are cost-effective biological delivery carrier. Plant-based vaccines are more reliable due to the lack of human pathogen or endotoxin, and oncogenic DNA.
Mahdi Ghatreh Samani
doaj +1 more source
Current Biology, 1998 DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
openaire +4 more sources
Expert Opinion on Emerging Drugs, 2003 There is increasing recognition that the unique antigenicities of the different stages of the Plasmodium spp. life cycle, the requirement for distinct immune mechanisms targeting these different stages, the immense allelic variation of parasites in the field, and the genetic heterogeneity of the target population pose enormous obstacles to the ...
Hedstrom, Richard C., Doolan, Denise L.
+10 more sources
Genome Medicine, 2021 Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li +17 more
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