Results 1 to 10 of about 166,548 (251)

Pre‐Clinical Development of Two DNA Vaccines Encoding MrkA of Klebsiella pneumoniae: Effect of Plasmid Backbone on Immunogenicity and Protective Efficacy Against Sepsis [PDF]

Microbial Biotechnology
Development of vaccines against Klebsiella pneumoniae has potential to prevent infections in both community and hospital settings and reduce associated mortality and morbidity worldwide.
Marta Vicente‐Pazos, Estéfani García‐Ríos, Laura Quílez‐Agraz, Gal·la Ustrell‐Sallent, Pilar Pérez‐Romero, Mireia López‐Siles, Michael J. McConnell   +6 more
doaj   +2 more sources

The potential of plant-based vaccines [PDF]

Future Natural Products, 2022
Plants are cost-effective biological delivery carrier. Plant-based vaccines are more reliable due to the lack of human pathogen or endotoxin, and oncogenic DNA.
Mahdi Ghatreh Samani
doaj   +1 more source

Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

Genome Medicine, 2021
Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders   +17 more
doaj   +1 more source

Have mRNA vaccines sentenced DNA vaccines to death?

Expert Review of Vaccines, 2023
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
doaj   +1 more source

Nucleic Acid Vaccines: A Rising Antidote for the Future

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022
DNA vaccines, a type of nucleic acid vaccine, have emerged as one of the recent developments in immunology and recombinant DNA technology, offering great potential in terms of ease of manufacture, maintenance, and safety compared to conventional vaccines.
W. Roseybala Devi, Supriya S. Kammar, S. Logesh, Gareth L. Dsouza, Thotegowdanapalya C. Mohan, Charukesi Rajulu   +5 more
doaj   +1 more source

Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins

Frontiers in Immunology, 2021
IntroductionBorrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines. DNA tattoo vaccination with B.
Michelle J. Klouwens, Michelle J. Klouwens, Michelle J. Klouwens, Jos J. A. Trentelman, Alex Wagemakers, Jasmin I. Ersoz, Adriaan D. Bins, Adriaan D. Bins, Joppe W. Hovius, Joppe W. Hovius, Joppe W. Hovius   +10 more
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Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization

Vaccine: X, 2019
Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells ...
Haruhiko Murata, Romelda Omeir, Wei Tu, Lynda Lanning, Kathryn Phy, Gideon Foseh, Andrew M. Lewis, Jr., Keith Peden   +7 more
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Toward QbD Process Understanding on DNA Vaccine Purification Using Design of Experiment

Frontiers in Bioengineering and Biotechnology, 2021
DNA vaccines, the third generation of vaccines, are a promising therapeutic option for many diseases as they offer the customization of their ability on protection and treatment with high stability.
Lalintip Hocharoen, Sarawuth Noppiboon, Panit Kitsubun   +2 more
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Genetic (DNA) Vaccines

Проблемы особо опасных инфекций, 2010
With the development of various branches of medicine and biology the classical ideas about means to prevent infectious diseases have changed. Nowadays in different countries of the world, investigations are carried out intensively in the sphere of ...
Yu. A. Popov, N. I. Mikshis
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Recent advances in delivery of veterinary DNA vaccines against avian pathogens

Veterinary Research, 2019
Veterinary vaccines need to have desired characteristics, such as being effective, inexpensive, easy to administer, suitable for mass vaccination and stable under field conditions.
Seyed Davoud Jazayeri, Chit Laa Poh
doaj   +1 more source