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Journal of Internal Medicine, 2003 Abstract. Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a review (Review). J Intern Med 2003; 253: 402–410.The DNA vaccines are simple rings of DNA containing a gene encoding an antigen, and a promoter/terminator to make the gene express in mammalian cells.
Margaret A Liu
exaly +3 more sources
Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses [PDF]
VirusesSingle-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses.
Peter Pushko +3 more
doaj +2 more sources
The DNA Vaccines for the Gn and Gc Heterologous Polymer of Severe Fever with Thrombocytopenia Syndrome Virus Induce Potent Immunogenicity in Mice [PDF]
VaccinesIntroduction/Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a threat to global public health with a mortality rate of up to 30%. However, there is currently no commercialized SFTSV vaccine.
Qiuju He +8 more
doaj +2 more sources
New insights for the development of efficient DNA vaccines [PDF]
Microbial BiotechnologyDespite the great potential of DNA vaccines for a broad range of applications, ranging from prevention of infections, over treatment of autoimmune and allergic diseases to cancer immunotherapies, the implementation of such therapies for clinical ...
Simone Berger +3 more
doaj +2 more sources
DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond [PDF]
Vaccines, 2023 We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received ...
Joel N. Maslow +8 more
doaj +2 more sources
Japanese Journal of Pharmacology, 2000 DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages
Koide, Yukio +3 more
+8 more sources
Current Biology, 1998 DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
openaire +4 more sources
Expert Opinion on Emerging Drugs, 2003 There is increasing recognition that the unique antigenicities of the different stages of the Plasmodium spp. life cycle, the requirement for distinct immune mechanisms targeting these different stages, the immense allelic variation of parasites in the field, and the genetic heterogeneity of the target population pose enormous obstacles to the ...
Hedstrom, Richard C., Doolan, Denise L.
+10 more sources
Brucella abortus RB51 lipopolysaccharide influence as an adjuvant on the therapeutic efficacy of HPV16 L1 and HPV16 E7 DNA vaccines [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Human papillomavirus (HPV) is a primary contributing agent of cervical cancer. Eradication of HPV-related infections requires therapeutic strategies.
Masoumeh Shirmohammadi +4 more
doaj +1 more source