Results 41 to 50 of about 1,806,959 (282)

Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins

Frontiers in Immunology, 2021
IntroductionBorrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines. DNA tattoo vaccination with B.
Michelle J. Klouwens, Michelle J. Klouwens, Michelle J. Klouwens, Jos J. A. Trentelman, Alex Wagemakers, Jasmin I. Ersoz, Adriaan D. Bins, Adriaan D. Bins, Joppe W. Hovius, Joppe W. Hovius, Joppe W. Hovius   +10 more
doaj   +1 more source

An investigation of novel DNA based vaccines for protection against Brucellosis [PDF]

This thesis describes design, construction and evaluation in a BALB/c mouse model, for five novel Brucella specific DNA vaccines. Brucellosis is worldwide zoonosis of economic significance that poses a significant threat to both animal and human health ...
Commander, Nicola Jane
core   +1 more source

Antirabies DNA Immunization

Проблемы особо опасных инфекций, 2010
Cited are literary data related to the development of DNA vaccines against rabies virus. Research results regarding gene vaccination of different models of laboratory animals and different ways of vaccine introduction are presented.
I. V. Tuchkov, A. K. Nikiforov
doaj   +1 more source

Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity. [PDF]

Hum Vaccin Immunother
The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored for several other pathogens.
Stirling DC, de Miguel Ferrer M, Kim S, Wane M, Kysh D, Caproni LJ, Tregoning JS.   +6 more
europepmc   +2 more sources

mRNA-Based Vaccines

, 2021
Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread.
Fred Zepp, Frank Kowalzik, Stephan Gehring, Daniel Schreiner, Daniel Teschner, Christian Jensen   +5 more
core   +1 more source

Characterization of a Novel Chimeric Theileria parva p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice [PDF]

, 2022
The current method to protect cattle against East Coast Fever (ECF) involves the use of live Theileria parva sporozoites. Although this provides immunity, using live parasites has many disadvantages, such as contributing to the spread of ECF.
van Diepen, Michiel, Leah Whittle, Chapman, Ros, Edward P. Rybicki, Williamson, Anna-Lise, Rybicki, Edward P, Michiel van Diepen, Anna-Lise Williamson, Whittle, Leah, Ros Chapman   +9 more
core   +1 more source

Toward QbD Process Understanding on DNA Vaccine Purification Using Design of Experiment

Frontiers in Bioengineering and Biotechnology, 2021
DNA vaccines, the third generation of vaccines, are a promising therapeutic option for many diseases as they offer the customization of their ability on protection and treatment with high stability.
Lalintip Hocharoen, Sarawuth Noppiboon, Panit Kitsubun   +2 more
doaj   +1 more source

The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice

, 2023
In recent years, lipid nanoparticles (LNPs) have emerged as a revolutionary technology for vaccine delivery. LNPs serve as an integral component of mRNA vaccines by protecting and transporting the mRNA payload into host cells. Despite their prominence in
Sathya N. Thulasi Raman, Jun Gao, Caroline Gravel, Levi Tamming, Michael J. W. Johnston, Jonathon Cecillon, Xuguang Li, Michael Rosu-Myles, Grant Frahm, Casey Lansdell, Annabelle Pfeifle, Wanyue Zhang, Lisheng Wang, Simon Sauve   +13 more
core   +1 more source

Efficacy of DNA Vaccines in Protecting Rainbow Trout against VHS and IHN under Intensive Farming Conditions

, 2022
Despite the negative impact of viral hemorrhagic septicemia (VHS) and infectious hematopoietic necrosis (IHN) on European rainbow trout farming, no vaccines are commercially available in Europe.
Alessandra Buratin, Rasmussen, Jesper S., Francesco Pascoli, Luana Cortinovis, Pretto, Tobia, Toffan, Anna, Biasini, Lorena, Marco Vanelli, Abbadi, Miriam, Cortinovis, Luana, Paola Berto, Lorena Biasini, Simona Perulli, Manfrin, Amedeo, Vendramin, Niccolò, Pascoli, Francesco, Vanelli, Marco, Anna Toffan, Perulli, Simona, Amedeo Manfrin, Dagoberto Sepúlveda, Buratin, Alessandra, Andrea Marsella, Miriam Abbadi, Niccolò Vendramin, Berto, Paola, Tobia Pretto, Jesper S. Rasmussen, Sepúlveda, Dagoberto, Niels Lorenzen, Marsella, Andrea, Lorenzen, Niels   +31 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source