Results 31 to 40 of about 171,936 (284)

Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity. [PDF]

Hum Vaccin Immunother
The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored for several other pathogens.
Stirling DC, de Miguel Ferrer M, Kim S, Wane M, Kysh D, Caproni LJ, Tregoning JS.   +6 more
europepmc   +2 more sources

Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma

OncoImmunology, 2018
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8+ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens.
Felipe Gálvez-Cancino, Ernesto López, Evelyn Menares, Ximena Díaz, Camila Flores, Pablo Cáceres, Sofía Hidalgo, Ornella Chovar, Marcela Alcántara-Hernández, Vincenzo Borgna, Manuel Varas-Godoy, Flavio Salazar-Onfray, Juliana Idoyaga, Alvaro Lladser   +13 more
doaj   +1 more source

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. [PDF]

, 2004
BACKGROUND: Many malaria vaccines are currently in development, although very few have been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME)- thrombospondin-related adhesion protein (TRAP) candidate vaccines are designed ...
Greenwood, Brian M, Pauline Kaye, Hill Adrian S. V, Kaye, Pauline, Imoukhuede, Egeruan B, Gilbert, Sarah, Walraven, G, Vasee S Moorthy, Moorthy Vasee S, Hill, AS, Egeruan B Imoukhuede, Kalifa Bojang, Milligan Paul, Gilbert, Sarah C, Pinder Margaret, Walraven, Gijs, Margaret Pinder (1712), Gijs Walraven, Adrian S V Hill, Hill, Adrian SV, Imoukhuede, EB, Egeruan B Imoukhuede (57141), Brian M Greenwood (45474), Walraven Gijs, Bojang, Kalifa, Brian M Greenwood, Keating, S, Vasee S Moorthy (57140), Greenwood Brian M, Sarah C Gilbert, Gilbert, SC, Kalifa Bojang (57143), Greenwood, BM, Bojang, K, Paul Milligan (57142), Pauline Kaye (57145), Gijs Walraven (18413), Moorthy, Vasee S, Kaye, P, Gilbert Sarah C, Pinder, M, Keating, Sheila, Sarah C Gilbert (57146), Paul Milligan, Sheila Keating (57144), Milligan, Paul, Moorthy, VS, Adrian S. V Hill (57147), Bojang Kalifa, Kaye Pauline, Sheila Keating, Milligan, P, Margaret Pinder, Keating Sheila, Pinder, Margaret, Imoukhuede Egeruan B   +55 more
core   +1 more source

Have mRNA vaccines sentenced DNA vaccines to death?

Expert Review of Vaccines, 2023
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
doaj   +1 more source

Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

Genome Medicine, 2021
Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders   +17 more
doaj   +1 more source

The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice

, 2023
In recent years, lipid nanoparticles (LNPs) have emerged as a revolutionary technology for vaccine delivery. LNPs serve as an integral component of mRNA vaccines by protecting and transporting the mRNA payload into host cells. Despite their prominence in
Sathya N. Thulasi Raman, Jun Gao, Caroline Gravel, Levi Tamming, Michael J. W. Johnston, Jonathon Cecillon, Xuguang Li, Michael Rosu-Myles, Grant Frahm, Casey Lansdell, Annabelle Pfeifle, Wanyue Zhang, Lisheng Wang, Simon Sauve   +13 more
core   +1 more source

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

Human Vaccines & Immunotherapeutics, 2017
We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models.
Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Recent advances in delivery of veterinary DNA vaccines against avian pathogens

Veterinary Research, 2019
Veterinary vaccines need to have desired characteristics, such as being effective, inexpensive, easy to administer, suitable for mass vaccination and stable under field conditions.
Seyed Davoud Jazayeri, Chit Laa Poh
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

mRNA-Based Vaccines

, 2021
Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread.
Fred Zepp, Frank Kowalzik, Stephan Gehring, Daniel Schreiner, Daniel Teschner, Christian Jensen   +5 more
core   +1 more source