Results 31 to 40 of about 1,806,959 (282)

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

Vaccines, 2020
The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success.
Sophia M. Reeder, Emma L. Reuschel, Mamadou A. Bah, Kun Yun, Nicholas J. Tursi, Kevin Y. Kim, Jacqueline Chu, Faraz I. Zaidi, Ilknur Yilmaz, Robert J. Hart, Benjamin Perrin, Ziyang Xu, Laurent Humeau, David B. Weiner, Ahmed S. I. Aly   +14 more
doaj   +1 more source

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. [PDF]

, 2004
BACKGROUND: Many malaria vaccines are currently in development, although very few have been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME)- thrombospondin-related adhesion protein (TRAP) candidate vaccines are designed ...
Greenwood, Brian M, Pauline Kaye, Hill Adrian S. V, Kaye, Pauline, Imoukhuede, Egeruan B, Gilbert, Sarah, Walraven, G, Vasee S Moorthy, Moorthy Vasee S, Hill, AS, Egeruan B Imoukhuede, Kalifa Bojang, Milligan Paul, Gilbert, Sarah C, Pinder Margaret, Walraven, Gijs, Margaret Pinder (1712), Gijs Walraven, Adrian S V Hill, Hill, Adrian SV, Imoukhuede, EB, Egeruan B Imoukhuede (57141), Brian M Greenwood (45474), Walraven Gijs, Bojang, Kalifa, Brian M Greenwood, Keating, S, Vasee S Moorthy (57140), Greenwood Brian M, Sarah C Gilbert, Gilbert, SC, Kalifa Bojang (57143), Greenwood, BM, Bojang, K, Paul Milligan (57142), Pauline Kaye (57145), Gijs Walraven (18413), Moorthy, Vasee S, Kaye, P, Gilbert Sarah C, Pinder, M, Keating, Sheila, Sarah C Gilbert (57146), Paul Milligan, Sheila Keating (57144), Milligan, Paul, Moorthy, VS, Adrian S. V Hill (57147), Bojang Kalifa, Kaye Pauline, Sheila Keating, Milligan, P, Margaret Pinder, Keating Sheila, Pinder, Margaret, Imoukhuede Egeruan B   +55 more
core   +2 more sources

DNA vaccines

Allergy, 1999
Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) virus are worldwide problems often leading to the development of chronic liver disease and hepatocellular carcinoma. Genetic immunizations with DNA encoding for structural and nonstructural proteins of HCV and HBV in experimental mice generate a broad base CD4+ and CD8+ cellular immune ...
H L, Spiegelberg, E, Raz
openaire   +4 more sources

Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

Genome Medicine, 2021
Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders   +17 more
doaj   +1 more source

Have mRNA vaccines sentenced DNA vaccines to death?

Expert Review of Vaccines, 2023
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
doaj   +1 more source

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

Human Vaccines & Immunotherapeutics, 2017
We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models.
Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Recent advances in delivery of veterinary DNA vaccines against avian pathogens

Veterinary Research, 2019
Veterinary vaccines need to have desired characteristics, such as being effective, inexpensive, easy to administer, suitable for mass vaccination and stable under field conditions.
Seyed Davoud Jazayeri, Chit Laa Poh
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

Human Vaccines & Immunotherapeutics, 2018
HIV-specific T-cell responses play a key role in controlling HIV infection, and therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on the T-cell responses induced by infection.
Paul Munson, Yi Liu, Debra Bratt, James T. Fuller, Xintao Hu, George N. Pavlakis, Barbara K. Felber, James I. Mullins, Deborah Heydenburg Fuller   +8 more
doaj   +1 more source

DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire [PDF]

, 2008
The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets.
Buchan, Sarah L., Timothy J. Kendall, Philip D. Greenberg, Michelle L. Dossett, Stuart N. Dunn, Öhlén, Claes, Rice, Jason, Dossett, Michelle L., Dossett, Michelle L, Stevenson, Freda K., Kendall, Timothy J., Sarah L. Buchan, Freda K. Stevenson, Dunn, Stuart N, Greenberg, Philip D, Dunn, Stuart N., Greenberg, Philip D., Kendall, Timothy J; id_orcid, Stevenson, Freda K, Jason Rice, Buchan, Sarah L, Claes Öhlén   +21 more
core   +1 more source