Results 11 to 20 of about 1,806,959 (282)
Current Molecular Medicine, 2001 Within the last decade bacterial plasmids encoding foreign antigens have revolutionized vaccine design. Although no DNA vaccine has yet been approved for routine human or veterinary use, the potential of this vaccine modality has been demonstrated in experimental animal models.
Reyes-Sandoval, A, Ertl, H
core +5 more sources
Minicircle DNA Vaccines: Overcoming Delivery and Expression Barriers in Next-Generation Immunization. [PDF]
Vaccines (Basel)DNA vaccines have emerged as a promising immunization platform, offering key advantages over conventional vaccine approaches, including superior stability, a favorable safety profile, rapid and flexible antigen design, and scalable manufacturing. However,
Alduhaymi IS +10 more
europepmc +2 more sources
DNA Vaccines: Their Formulations, Engineering and Delivery. [PDF]
Vaccines (Basel)The concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent many diseases ...
Kozak M, Hu J.
europepmc +2 more sources
Current Biology, 1998 DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
openaire +4 more sources
Current Protocols in Human Genetics, 2003 There is increasing recognition that the unique antigenicities of the different stages of the Plasmodium spp. life cycle, the requirement for distinct immune mechanisms targeting these different stages, the immense allelic variation of parasites in the field, and the genetic heterogeneity of the target population pose enormous obstacles to the ...
Hedstrom, Richard C., Doolan, Denise L.
+11 more sources
Analysis of Promising Approaches to COVID-19 Vaccine Development
Биопрепараты: Профилактика, диагностика, лечение, 2020 The number of confirmed COVID-19 cases worldwide amounted to 50 million at the beginning of November 2020. This is clearly not enough for the formation of herd immunity, which will prevent repeated outbreaks of the disease.
G. G. Onishchenko +3 more
doaj +1 more source
Nucleic acid vaccines for human papillomavirus; prevention or treatment [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2019 Introduction: Cervical cancer is the fourth common cancer among women. In almost all cases of this cancer, infection to a high risk human papilloma virus (HPV) especially type 16 and 18 is observed.
Solmaz Moniri Javadhesari +2 more
doaj +1 more source
DNA vaccines and recombinant allergens with reduced allergenic activity treat allergies
Russian Open Medical Journal, 2021 This review is intended to familiarize readers with major novel directions of developing allergy vaccines, their structure, as well as the mechanisms of forming a new immunological response in the course of the treating immunoglobulin E (IgE)-mediated ...
Stanislava Yu. Petrova +4 more
doaj +1 more source
New vaccines on the horizon [PDF]
Arhiv za farmaciju, 2019 Vaccines are considered to be one of the greatest public health achievements of the last century. As a result of widespread vaccine use, the smallpox virus has been completely eradicated and the incidence of other diseases such as polio, measles, tetanus
Arsenović-Ranin Nevena
doaj +1 more source
Allergy vaccines for specific immunotherapy
Журнал микробиологии, эпидемиологии и иммунобиологии, 2021 Allergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades.
S. Yu. Petrova +3 more
doaj +1 more source