Results 21 to 30 of about 161,535 (242)

DNA vaccines and recombinant allergens with reduced allergenic activity treat allergies

Russian Open Medical Journal, 2021
This review is intended to familiarize readers with major novel directions of developing allergy vaccines, their structure, as well as the mechanisms of forming a new immunological response in the course of the treating immunoglobulin E (IgE)-mediated ...
Stanislava Yu. Petrova, Svetlana V. Khlgatian, Elena V. Svirshchevskaya, Anna V. Vasilyeva, Valentina M. Berzhets   +4 more
doaj   +1 more source

Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization

Vaccine: X, 2019
Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells ...
Haruhiko Murata, Romelda Omeir, Wei Tu, Lynda Lanning, Kathryn Phy, Gideon Foseh, Andrew M. Lewis, Jr., Keith Peden   +7 more
doaj   +1 more source

Allergy vaccines for specific immunotherapy

Журнал микробиологии, эпидемиологии и иммунобиологии, 2021
Allergen-specific immunotherapy (ASIT) has been used for more than a hundred years to treat patients with IgEmediated allergic diseases. The most common allergens have been obtained using molecular cloning technology in the past two decades.
S. Yu. Petrova, S. V. Khlgatian, V. M. Berzhets, A. V. Vasileva   +3 more
doaj   +1 more source

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

Vaccines, 2020
The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success.
Sophia M. Reeder, Emma L. Reuschel, Mamadou A. Bah, Kun Yun, Nicholas J. Tursi, Kevin Y. Kim, Jacqueline Chu, Faraz I. Zaidi, Ilknur Yilmaz, Robert J. Hart, Benjamin Perrin, Ziyang Xu, Laurent Humeau, David B. Weiner, Ahmed S. I. Aly   +14 more
doaj   +1 more source

DNA vaccines

Allergy, 1999
Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) virus are worldwide problems often leading to the development of chronic liver disease and hepatocellular carcinoma. Genetic immunizations with DNA encoding for structural and nonstructural proteins of HCV and HBV in experimental mice generate a broad base CD4+ and CD8+ cellular immune ...
H L, Spiegelberg, E, Raz
openaire   +4 more sources

Genetic (DNA) Vaccines

Проблемы особо опасных инфекций, 2010
With the development of various branches of medicine and biology the classical ideas about means to prevent infectious diseases have changed. Nowadays in different countries of the world, investigations are carried out intensively in the sphere of ...
Yu. A. Popov, N. I. Mikshis
doaj   +1 more source

DENV-3 precursor membrane (prM) glycoprotein enhances E protein immunogenicity and confers protection against DENV-2 infections in a murine model

Human Vaccines & Immunotherapeutics, 2021
To improve a DNA vaccine containing the truncated dengue virus serotype 2 (DENV-2) envelope (E) protein and evaluate the influence of precursor membrane (prM) glycoprotein polymorphism on E protein immunogenicity, two vaccine candidates have been ...
Roberto S. Dias, Michelle D. Teixeira, Mariana F. Xisto, John W. O. Prates, Jessica D. Da Silva, Iago O. Mello, Cynthia C. Da Silva, Sérgio O. De Paula   +7 more
doaj   +1 more source

Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma

OncoImmunology, 2018
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8+ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens.
Felipe Gálvez-Cancino, Ernesto López, Evelyn Menares, Ximena Díaz, Camila Flores, Pablo Cáceres, Sofía Hidalgo, Ornella Chovar, Marcela Alcántara-Hernández, Vincenzo Borgna, Manuel Varas-Godoy, Flavio Salazar-Onfray, Juliana Idoyaga, Alvaro Lladser   +13 more
doaj   +1 more source

Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

Genome Medicine, 2021
Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders   +17 more
doaj   +1 more source

Have mRNA vaccines sentenced DNA vaccines to death?

Expert Review of Vaccines, 2023
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
doaj   +1 more source