Results 41 to 50 of about 161,433 (154)
Plasmid DNA-based Alphavirus Vaccines
Vaccines, 2019 Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
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Ensuring safety of DNA vaccines
Microbial Cell Factories, 2005 In 1990 a new approach for vaccination was invented involving injection of plasmid DNA in vivo, which elicits an immune response to the encoded protein. DNA vaccination can overcome most disadvantages of conventional vaccine strategies and has potential ...
Wessels Stephen, Glenting Jacob
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DNA vaccines for viral diseases
Brazilian Journal of Medical and Biological Research, 1999 DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization.
J.J. Donnelly, J.B. Ulmer
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Bulletin of the National Research Centre, 2020 Background Poultry bacterial pathogens are mainly controlled by using high-cost sanitary measures and medical treatment. However, the drug-resistant strains of pathogens continuously emerge, and medical treatments are often ineffective.
Nagwa S. Rabie, Zeinab M. S. Amin Girh
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, 2005 The DNA vaccine has proven to be one of the most promising applications in the field of gene therapy. Due to its unique ability to readily induce humoral as well as cellular immune responses, it attracted great interest when the concept was first confirmed in the early 1990s.
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Advances in nucleic acid-based cancer vaccines
Journal of Biomedical ScienceNucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic.
Hung-Chun Liao, Shih-Jen Liu
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Vaccines, 2014 Since the initial proof-of-concept studies examining the ability of antigen-encoded plasmid DNA to serve as an immunogen, DNA vaccines have evolved as a clinically safe and effective platform for priming HIV-specific cellular and humoral responses in ...
Smita S. Iyer, Rama R. Amara
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Research progress of tumor vaccines in the treatment of prostate cancer
结直肠肛门外科Prostate cancer (PCa) is one of the most common malignancies threatening the health of elderly men. In recent years, immunotherapy has emerged as a new field in the treatment of PCa, aiming to kill tumor cells by activating the body’s immune system ...
Chen Zheng +3 more
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Journal of Immunology Research, 2018 There remains a need for vaccines that can safely and effectively protect against the biological threat agents Venezuelan (VEEV), western (WEEV), and eastern (EEEV) equine encephalitis virus.
Lesley C. Dupuy +4 more
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DNA Vaccines: Their Formulations, Engineering and Delivery
VaccinesThe concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent many diseases ...
Michael Kozak, Jiafen Hu
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