Results 191 to 200 of about 191,032 (247)

An open-label study on the safety and immunogenicity of a PD-1-enhanced DNA vaccine used as a T cell booster for COVID-19. [PDF]

EBioMedicine
Wong YC, Hang Ho DH, Zhou R, Zhang R, Woo KF, Cheng WY, Wang T, Du Y, Polly Pang KP, Tai WK, Jin X, Chen Z, Ngai Hung IF.   +12 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Bioinformatics Analysis and Immunogenicity Assessment of the Novel Multi-Stage DNA Vaccine W541 Against Mycobacterium Tuberculosis. [PDF]

Immun Inflamm Dis
Yang Y, Xue Y, Wang X, Wang L, Wang J, Zhang J, Liu Y, Liang Y, Wu X.   +8 more
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, EarlyView.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Skin patch delivery of a SARS-CoV-2 spike DNA vaccine produces broad neutralising antibody responses. [PDF]

Heliyon
McMillan CLD, Corner AV, Wijesundara DK, Choo JJY, Pittayakhajonwut D, Poredi I, Parry RH, Bindra GK, Bruce KL, Khromykh AA, Fernando GJP, Dapremont L, Young PR, Muller DA.   +13 more
europepmc   +1 more source

Extended HPV typing as an efficient alternative within HPV‐based screening programs

International Journal of Cancer, EarlyView.
What's New? Extended high‐risk human papillomavirus (hrHPV) typing holds promise for improving cervical intraepithelial neoplasia grade 3 (CIN3) detection, particularly as vaccinated cohorts may shift the prevalence of oncogenic HPV types. The authors of this study evaluated extended hrHPV genotyping within a public screening program involving women ...
Joacim Meneses‐León, Berenice Rivera‐Paredez, Sonia Hernández‐Salazar, Leticia Torres‐Ibarra, Martha Carnalla, Leith León‐Maldonado, Rubí Hernández‐López, José Damián Cadena‐Fiscal, Anna B. Moscicki, Manuel Quiterio‐Trenado, Eduardo Lazcano‐Ponce, Jorge Salmerón   +11 more
wiley   +1 more source

Molecular Analysis and Bioinformatics Assessment of Full-Length L1 Gene of Bovine Papillomavirus Type-1 as a Potential DNA Vaccine Study. [PDF]

Vet Med Int
Abdul-Zahra HH, Khudhair YI, Al-Hraishawi HR.   +2 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Immune efficacy of <i>oprH</i> chitosan nanoparticle DNA vaccine against <i>Pseudomonas aeruginosa</i>. [PDF]

Iran J Vet Res
Qiang G, Yajing L, Shiji Z, Jiayu T, Jingwen L.   +4 more
europepmc   +1 more source

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source