Results 191 to 200 of about 347,060 (291)

DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action. [PDF]

NPJ Vaccines
Yu H, Shi J, Fu G, Cao Z, Qiu R, Zhao T, Zhang J, Lan Y, Guan J, Zhao K, Gao F, He W, Li Z.   +12 more
europepmc   +1 more source

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma [PDF]

, 2019
Artyomov, Maxim N., Bender, Diane, Campian, Jian L., Chicoine, Michael R., Dacey, Ralph G., Dunn, Gavin P., Fritsch, Edward F., Gillanders, William E., Huang, Jiayi, Johanns, Tanner M., Kobayashi, Dale K., Liu, Connor J., Mardis, Elaine R., Miller, Christopher A., Perrin, Richard J., Schreiber, Robert D.   +15 more
core   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Evaluation of Immunogenicity of <i>Mycobacterium tuberculosis ag85ab</i> DNA Vaccine Delivered by Pulmonary Administration. [PDF]

Vaccines (Basel)
Zhao H, Zhang Z, Xue Y, Wang N, Liu Y, Ma X, Wang L, Wang X, Zhang D, Zhang J, Wu X, Liang Y.   +11 more
europepmc   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

Biotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman, Emily Lathrop, Aurelia Attal‐Juncqua, Matthew Nicotra, Allison Berke   +4 more
wiley   +1 more source

Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza. [PDF]

Vaccines (Basel)
Lin H, Jiang Y, Li Y, Zhong Y, Chen M, Jiang W, Xiang R, Cao N, Sun L, Wang X, Lu L, Wang Q, Han G, Ma D, Wang B.   +14 more
europepmc   +1 more source

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji, Kosuke Kusamori, Chihiro Tanaka, Hideki Sakai, Shoko Itakura, Makiya Nishikawa   +5 more
wiley   +1 more source

Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs. [PDF]

Vaccines (Basel)
Huo H, Wang H, Liang S, Wang Z, Wang J, Wang Q, Li C, Tao Y, Ge J, Wen Z, Wang J, Chen W, Wang X, Shuai L, Bu Z.   +14 more
europepmc   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2. [PDF]

Front Immunol
Sood S, Gary EN, Matar M, Kim J, Hojecki CE, Warner B, Vendramelli R, Truong T, Smith A, Rice J, Sparks J, DeSalvo M, Henderson J, Rogers JA, Sharma A, Pessaint L, Iavarone CA, Kobasa D, Boyer JD, Lindborg S, Anwer K.   +20 more
europepmc   +1 more source