Results 181 to 190 of about 195,479 (250)

Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses

Biotechnology Progress, EarlyView.
Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing, Tomoki Igi, Daniel Strauss   +2 more
wiley   +1 more source

Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza. [PDF]

Vaccines (Basel)
Lin H, Jiang Y, Li Y, Zhong Y, Chen M, Jiang W, Xiang R, Cao N, Sun L, Wang X, Lu L, Wang Q, Han G, Ma D, Wang B.   +14 more
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2. [PDF]

Front Immunol
Sood S, Gary EN, Matar M, Kim J, Hojecki CE, Warner B, Vendramelli R, Truong T, Smith A, Rice J, Sparks J, DeSalvo M, Henderson J, Rogers JA, Sharma A, Pessaint L, Iavarone CA, Kobasa D, Boyer JD, Lindborg S, Anwer K.   +20 more
europepmc   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Enhanced HIV immune responses elicited by an apoptotic single-cycle SHIV lentivector DNA vaccine. [PDF]

Front Cell Infect Microbiol
Bose D, Rogers KA, Shirreff LM, Chebloune Y, Villinger FJ.   +4 more
europepmc   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Development and evaluation of protective immunity of a ROP27 DNA vaccine against Eimeria tenella in chickens. [PDF]

Poult Sci
Zhao W, Niu Z, Liu K, Zhang X, Kang S, Dou K, Zhao J, Bai R, Zheng M, Lv X.   +9 more
europepmc   +1 more source