Results 21 to 30 of about 347,060 (291)

DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System [PDF]

Iranian Journal of Immunology, 2020
Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB.
Ahmad Mobed
doaj   +1 more source

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes [PDF]

, 2012
<p>Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the
AB Fredriksen, AB Pedersen, AE O'Connell, AE Schwab, B de Andres, B Manoury, BL Makepeace, BW Li, C Klotz, C Martin, C Martin, D Abraham, D Abraham, D Horst, D Knox, David W. Taylor, DH Barouch, DL Redmond, E Maraskovsky, G Ahlen, G Nchinda, GT Joseph, HA Farid, HongLin Luo, J Gardon, J Murray, JE Allen, JE Allen, JJ Donnelly, JP Hewitson, Judith E. Allen, KJ Fairlie-Clarke, KJ Ishii, LM Mir, LM Mir, LvG Jørgensen, MD Taylor, MD Taylor, MY Osei-Atweneboana, N Gomez-Escobar, Nick Gray, O Golden, PJ Hotez, R Ihaka, RM Maizels, RT Rwegoshora, S Babayan, S Frontier, S Mendez, S Ramachandran, S Thirugnanam, SA Babayan, SA Babayan, SB Anand, SB Anand, SB Anand, Simon A. Babayan, SM Sumida, Stephen John Davies, W Harnett, WF Gregory, WF Gregory, Y Dash, Y Wu   +63 more
core   +4 more sources

Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant

Scientific Reports, 2022
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. New technologies have been utilized to develop several types of vaccines to prevent the spread of SARS-CoV-2 ...
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami   +20 more
doaj   +1 more source

Epidemiology of Any and Vaccine-Type Anogenital Human Papillomavirus Among 13-26-Year-Old Young Men After HPV Vaccine Introduction [PDF]

, 2018
PURPOSE: The aims of this study were to determine prevalence of and factors associated with any human papillomavirus (HPV) and vaccine-type HPV among young men after vaccine introduction, stratified by vaccination status.
Bernstein, David I., Brown, Darron A., Chandler, Emmanuel, Ding, Lili, Franco, Eduardo L., Gorbach, Pamina, Kahn, Jessica A., Widdice, Lea E.   +7 more
core   +1 more source

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

Immunotherapeutic effects of Mycobacterium tuberculosis rv3407 DNA vaccine in mice

Autoimmunity, 2018
Tuberculosis (TB) is a major global public health problem. Latent TB infection (LTBI) is a major source of active TB. New vaccines to treat LTBI are urgently demanded.
Yan Liang, Yajing Zhao, Xuejuan Bai, Li Xiao, Yourong Yang, Junxian Zhang, Lan Wang, Lei Cui, Tong Wang, Yingchang Shi, Weiguo Zhao, Xueqiong Wu   +11 more
doaj   +1 more source

Advancements in the development of nucleic acid vaccines for syphilis prevention and control

Human Vaccines & Immunotherapeutics, 2023
Syphilis, a chronic systemic sexually transmitted disease, is caused by the bacterium Treponema pallidum (T. pallidum). Currently, syphilis remains a widespread infectious disease with significant disease burden in many countries.
Sijia Li, Weiwei Li, Yinqi Jin, Bin Wu, Yimou Wu   +4 more
doaj   +1 more source

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

Human Vaccines & Immunotherapeutics, 2017
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from
Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy   +7 more
doaj   +1 more source

Insight into the current Toxoplasma gondii DNA vaccine: a review article

Expert Review of Vaccines, 2023
Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan   +8 more
doaj   +1 more source

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

Human Vaccines & Immunotherapeutics, 2017
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza.
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard   +5 more
doaj   +1 more source