Results 21 to 30 of about 191,032 (247)

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

Human Vaccines & Immunotherapeutics, 2017
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza.
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard   +5 more
doaj   +1 more source

Insight into the current Toxoplasma gondii DNA vaccine: a review article

Expert Review of Vaccines, 2023
Introduction Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete ...
Xirui Zhang, Hao Yuan, Yasser S. Mahmmod, Zipeng Yang, Mengpo Zhao, Yining Song, Shengjun Luo, Xiu-Xiang Zhang, Zi-Guo Yuan   +8 more
doaj   +1 more source

An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice

Human Vaccines & Immunotherapeutics, 2017
Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of ...
Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Liposome‐mediated DNA vaccination [PDF]

FEBS Letters, 1997
Numerous reports have indicated that intramuscular injection of antigen‐coding naked plasmid DNA can trigger humoral and cell‐mediated protective immunity against infection. This follows DNA uptake by muscle fibres, leading to the expression and extracellular release of the antigen. Here it is shown for the first time that intramuscular immunization of
Gregoriadis, Gregory, Saffie, Roghieh, de Souza, J.Brian   +2 more
openaire   +2 more sources

Design and Cloning of the Optimized L1 Gene from Human Papilloma virus 18 into the Expression Vector PcDNA3 and Evaluating its Expression in a Eukaryotic System

Iranian South Medical Journal, 2023
Background: Vaccines have played a special role in controlling and reducing mortality from infectious diseases. In this regard, DNA vaccines were developed to ease the production and reduce the risks of traditional vaccines.
Maryam Rahimpour, Sirous Naeimi, Azam Rahimpour, Fatemeh Farshadpour, Reza Taherkhani   +4 more
doaj  

Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes

Vaccines, 2020
The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC-83 strain, was evaluated in mice.
Dylan M. Johnson, Kevin J. Sokoloski, Jenny D. Jokinen, Tia L. Pfeffer, Yong-Kyu Chu, Robert S. Adcock, Donghoon Chung, Irina Tretyakova, Peter Pushko, Igor S. Lukashevich   +9 more
doaj   +1 more source

DNA vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2013
Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their immunogenicity.
Coban, Cevayir, Kobiyama, Kouji, Jounai, Nao, Tozuka, Miyuki, Ishii, Ken J   +4 more
openaire   +2 more sources

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Human Vaccines & Immunotherapeutics, 2022
Genetic optimization of Nucleic Acid immunogens is important for potentially improving their immune potency. A COVID-19 DNA vaccine is in phase III clinical trial which is based on a promising highly developable technology platform.
Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B. Weiner, Kate Broderick, Bin Wang   +17 more
doaj   +1 more source

Dengue Vaccines: Current Status and Future Perspectives

APIK Journal of Internal Medicine
Dengue fever (DF), caused by the dengue virus (DENV), is a major public health problem worldwide, with approximately 390 million reported annual infections.
Vasantha Kamath, A. B. Aishwarya
doaj   +1 more source

Safety and long-term immunological effects of CryJ2-LAMP plasmid vaccine in Japanese red cedar atopic subjects: A phase I study

Human Vaccines & Immunotherapeutics, 2017
Japanese Red Cedar (JRC) pollen induced allergy affects one third of Japanese and the development of effective therapies remains an unachieved challenge.
Yan Su, Eliezer Romeu-Bonilla, Athanasia Anagnostou, David Fitz-Patrick, William Hearl, Teri Heiland   +5 more
doaj   +1 more source