Results 71 to 80 of about 3,025,811 (189)

Immunogenicity of experimental DNA vaccines encoding hemagglutinin and hemagglutinin stalk of influenza A (H5N8) virus

Сибирский научный медицинский журнал
Avian influenza A virus subtype H5 is widespread in the bird population, and there is a risk of its transmission to humans, therefore, it is necessary to develop an effective vaccine to prevent virus spread.
V. R. Litvinova, N. B. Rudometova, L. A. Kisakova, D. N. Kisakov, V. A. Yakovlev, E. V. Tigeeva, M. B. Borgoyakova, K. I. Ivanova, V. Yu. Marchenko, T. N. Ilyicheva, L. I. Karpenko, A. P. Rudometov, A. A. Ilyichev   +12 more
doaj   +1 more source

DNA Vaccines: Recent Developments and the Future

Vaccines, 2014
This special issue is focused on DNA vaccines, marking the two decades since the first demonstration of pre-clinical protection was published in Science (Ulmer et al.; Heterologous protection against influenza by injection of DNA encoding a viral protein.
B. Wahren, Margaret A. Liu
semanticscholar   +1 more source

Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

Journal of Infectious Diseases, 2014
Background Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mortality and are potential bioterrorism agents. There are no available vaccines or therapeutic agents.
Uzma N. Sarwar, Pamela J. M. Costner, M. Enama, N. Berkowitz, Zonghui Hu, C. S. Hendel, S. Sitar, Sarah H. Plummer, S. Mulangu, R. Bailer, R. Koup, J. Mascola, G. Nabel, N. Sullivan, B. Graham, J. Ledgerwood   +15 more
semanticscholar   +1 more source

Strategies and hurdles using DNA vaccines to fish

Veterinary Research, 2014
DNA vaccinations against fish viral diseases as IHNV at commercial level in Canada against VHSV at experimental level are both success stories. DNA vaccination strategies against many other viral diseases have, however, not yet yielded sufficient results
L. B. Hølvold, A. Myhr, R. Dalmo
semanticscholar   +1 more source

Trial watch: DNA-based vaccines for oncological indications

OncoImmunology, 2017
DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated.
Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene, Lorenzo Galluzzi   +7 more
doaj   +1 more source

DNA Vaccines for Emerging Infectious Diseases: What If?

Emerging Infectious Diseases, 1996
A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response.
Robert G. Whalen
doaj   +1 more source

DNA vaccines against influenza.

Acta Biochimica Polonica, 2014
Genetic vaccine technology has been considerably developed within the last two decades. This cost effective and promising strategy can be applied for therapy of cancers and for curing allergy, chronic and infectious diseases, such as a seasonal and ...
A. Stachyra, A. Góra-Sochacka, A. Sirko
semanticscholar   +1 more source

DNA Vaccines Approach: From Concepts to Applications

, 2014
DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases.
V. B. Pereira, Meritxell Zurita-Turk, T. Saraiva, C. P. Castro, B. M. Souza, P. M. Agresti, F. A. Lima, Vanessa Nathalie Pfeiffer, M. Azevedo, C. S. Rocha, D. Pontes, V. Azevedo, A. Miyoshi   +12 more
semanticscholar   +1 more source

Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials

Journal of Nanotechnology, 2012
Since the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity.
Kristin J. Flores, Michael Craig, Adam Wanekaya, Lifeng Dong, Kartik Ghosh, Joshua J. Smith, Robert K. DeLong   +6 more
doaj   +1 more source

Advances in nucleic acid-based cancer vaccines

Journal of Biomedical Science
Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic.
Hung-Chun Liao, Shih-Jen Liu
doaj   +1 more source