Results 11 to 20 of about 15,919 (234)

Novel Ex Vivo DOAC Removal Methods Reduce Interference in Lupus Anticoagulant Testing [PDF]

Diagnostics, 2022
Direct oral anticoagulants (DOAC) interfere in laboratory coagulation testing. The aim here was to study how commercial DOAC removal methods, DOAC Filter® and DOAC-Stop™, perform to eliminate DOAC concentrations and false positive results in lupus ...
Tuukka A Helin, Paula Savola, Lotta Joutsi-Korhonen   +2 more
exaly   +4 more sources

Direct Oral Anticoagulant Removal by a DOAC Filter: Impact on Lupus Anticoagulant Testing – Evaluation on Spiked and Patient Samples

Research and Practice in Thrombosis and Haemostasis, 2022
Background DOAC Filter (DF) is a new device to overcome interference in lupus anticoagulant (LAC) testing by direct oral anticoagulants (DOACs). Objectives We evaluated DOAC removal from plasma and elimination of DOAC interference in LAC testing by DF ...
Pieter M De Kesel, Katrien Devreese
exaly   +3 more sources

Uticaj DOAK i DOAC-REMOVE® na testove koagulacije u toku testiranja trombofilije kod bolesnika lečenih primenom DOAK [PDF]

Vojnosanitetski pregled, 2022
Background/Aim. Direct oral anticoagulants (DOACs) administration significantly interferes with coagulation as-says. The aim of the study was to evaluate the effect of DOACs and DOAC-Remove® on coagulation assays dur-ing thrombophilia testing.
Backović, Dragana, Kovač, Mirjana, Lalić-Ćosić, Sanja, Basarić Dušica, Tomić, Branko, Kovač Mirjana, Gvozdenov Maja, Lalić-Ćosić Sanja, Gvozdenov, Maja, Tomić Branko, Basarić, Dušica, Backović Dragana, Dusica Basaric, Sanja Lalic-Cosic, Branko Tomic, Dragana Backovic, Mirjana Kovac, Maja Gvozdenov   +17 more
core   +7 more sources

Evaluation of DOAC Dipstick Test for Detecting Direct Oral Anticoagulants in Urine Compared with a Clinically Relevant Plasma Threshold Concentration [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2022
Measuring direct oral anticoagulant (DOAC) concentrations might be necessary in certain clinical situations but is not routinely performed. The DOAC Dipstick is a new rapid test for detecting DOACs in urine.
Lenna Örd MD, Toomas Marandi MD, PhD, Marit Märk MD, Leonid Raidjuk MD, Jelena Kostjuk MD, Valdas Banys MD, PhD, Karit Krause, Marika Pikta MD   +7 more
doaj   +2 more sources

Comparing the Effect of DOAC-Stop® and DOAC-Remove® on Apixaban, Rivaroxaban and Dabigatran Prior to Thrombophilia and Lupus Testing [PDF]

British Journal of Biomedical Science
BackgroundDirect oral anticoagulants (DOACs) interfere with coagulation assays potentially leading to inaccurate results. This study determined the effectiveness of DOAC-stop® and DOAC-remove® in overcoming DOAC interference.
Noor-E.-Huddah Malik, Andrew Ward, Beth Erskine   +2 more
doaj   +2 more sources

Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire [PDF]

BMC Geriatrics
BACKGROUND: DOACs are increasingly prescribed for atrial fibrillation and venous thromboembolism due to their ease of use and lack of monitoring requirements.
Grymonprez, M., Janssen, D.JA., Robben, S.HM., De Jonghe, M., Winckers, K., Zwietering, A., Altintas, S., Eurlings, C., de Jong, M.J., Nicolai, S., Braeken, D., Pisters, R., De Backer, T., Joosten, H., ten Cate, H., Magdelijns, F.JH., Vaes, B., Brys, A.DH., Magdelijns, F J H, Grymonprez, M, Zwietering, A, Ten Cate, H, Joosten, H, de Jong, M. J., Janssen, D. J. A.; id_orcid, Janssen, D J A, Robben, S H M, Vaes, B, De Backer, T, Pisters, R, de Jong, M J, Nicolaï, S, Eurlings, C, Brys, A. D. H., Robben, S. H. M., Magdelijns, F. J. H., Altintas, S, Brys, A D H, Winckers, K, Braeken, D, De Jonghe, Michel   +40 more
core   +3 more sources

Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests [PDF]

TH Open, 2018
The impact of direct oral anticoagulants (DOACs) on laboratory assays used for thrombo- philia testing (e.g., antithrombin, protein S, protein C, lupus anticoagulant and activated protein-C resistance) is a well-known issue and may cause false-positive ...
Jacqmin, Hugues, Bérangère Devalet, Julie Vandepapeliere, Bernard Chatelain, Sabor, Lina, Devalet, Bérangère, Hugues Jacqmin, Jonathan Douxfils, Chatelain, Bernard, Favresse, Julien, Jacqmin Hugues, Vandepapelière, Julie, Douxfils, Jonathan; id_orcid, Maximilien Braibant, Douxfils Jonathan, Julien Favresse, Sarah Lessire, Lardinois, Benjamin, Benjamin Lardinois, François Mullier, Braibant Maximilien, Lina Sabor, Braibant, Maximilien, Mullier, François, Lessire, Sarah   +24 more
core   +6 more sources

DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation

Thrombosis and Haemostasis, 2022
In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present.
Huzjan, Arijana Lovrenčić, Brkljačić, Diana Delić, Weiss, Christel, Goreta, Sandra Šupraha, Hetjens, Svetlana, Lovrenčić Huzjan, Arijana, Bosnar Puretić, Marijana, Glojnarić, Anesa Čajević, Mioč, Pavao, Harenberg, Job, Margetić, Sandra, Ćelap, Ivana, Šupraha Goreta, Sandra, Delić Brkljačić, Diana, Puretić, Marijana Bosnar, Christel Weiss, Svetlana Hetjens, Anesa Čajević Glojnarić, Ivana Ćelap, Job Harenberg, Diana Delić Brkljačić, Arijana Lovrenčić Huzjan, Sandra Margetić, Marijana Bosnar Puretić, Sandra Šupraha Goreta, Pavao Mioč   +25 more
core   +3 more sources

Practical Nomogram Predicting Apixaban or Rivaroxaban Concentrations from Low-Molecular-Weight Heparin Anti-Xa Values: Special Interest in Acute Ischemic Stroke Patients [PDF]

Journal of Stroke, 2023
Background and Purpose In patients with acute ischemic stroke (AIS) using a direct oral factor-Xa anticoagulant (DOAC) during the last 48 hours, a fixed plasma heparin-calibrated anti-Xa activity (0.5 IU/mL) was proposed as a threshold below which ...
Charlyne Brakta, Alain Stépanian, Peggy Reiner, Maxime Delrue, Mikaël Mazighi, Emmanuel Curis, Virginie Siguret   +6 more
doaj   +1 more source

Low Exposure to Direct Oral Anticoagulants Is Associated with Ischemic Stroke and Its Severity [PDF]

Journal of Stroke, 2022
Background and purpose In acute stroke patients, plasma concentrations of direct oral anticoagulants (DOAC) at hospital admission only poorly mirror DOAC exposure or the coagulation status at the time of the event.
Timolaos Rizos, Andreas D. Meid, Andrea Huppertz, Chris Dumschat, Jan Purrucker, Kathrin I. Foerster, Jürgen Burhenne, David Czock, Ekkehart Jenetzky, Peter A. Ringleb, Walter E. Haefeli   +10 more
doaj   +1 more source