Results 11 to 20 of about 21,302 (228)

Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients with Atrial Fibrillation on Direct-Acting Oral Anticoagulants

Circulation, 2023
BACKGROUND: Current clinical decision tools for assessing bleeding risk in individuals with atrial fibrillation (AF) have limited performance and were developed for individuals treated with warfarin.
Rahul Aggarwal, C. Ruff, S. Virdone, S. Perreault, A. Kakkar, M. Palazzolo, M. Dorais, G. Kayani, Daniel E. Singer, E. Secemsky, J. Piccini, Usman A. Tahir, Changyu Shen, R. Yeh   +13 more
semanticscholar   +1 more source

Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis

Рациональная фармакотерапия в кардиологии, 2023
Aim. To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis.Material and methods.
L. V. Fedina, I. N. Sychev, T. D. Rastvorova, E. V. Strigunkova, A. A. Kachanova, Z. A. Sozaeva, P. O. Bochkov, A. V. Vardanyan, K. B. Mirzayev, D. A. Sychev   +9 more
doaj   +1 more source

Comparison of the DOAC Dipstick Test on Urine Samples With Chromogenic Substrate Methods on Plasma Samples in Outpatients Treated With Direct Oral Anticoagulants

Clinical and applied thrombosis/hemostasis, 2023
Identifying adherence to direct oral anticoagulants (DOACs) plays a major role in treatment efficacy and safety. The DOAC Dipstick can detect DOACs in urine samples of acutely diseased patients at plasma thresholds of about 30 ng/mL.
L. Papageorgiou, S. Hetjens, J. Fareed, Sanny Auge, Laetitia Tredler, J. Harenberg, C. Weiss, I. Elalamy, G. Gerotziafas   +8 more
semanticscholar   +1 more source

DOAC-associated bleeding, hemostatic strategies, and thrombin generation assays - a review of the literature.

Journal of Thrombosis and Haemostasis, 2022
Direct oral anticoagulants (DOACs) account for most oral anticoagulant use. DOAC-associated bleeding events are commonly encountered in clinical practice and are associated with substantial morbidity and mortality.
Joseph R. Shaw, L. Castellucci, D. Siegal, M. Carrier   +3 more
semanticscholar   +1 more source

The Saudi Consensus for the Management of Cancer-Associated Thromboembolism: A Modified Delphi-Based Study

TH Open, 2023
Background Cancer is a well-known risk factor of preventable thromboembolic disease. This study aims to provide guidance on the prevention and management of cancer-associated thrombosis (CT) that tailors prophylactic and therapeutic options for medical ...
Mohammed Alsheef, Shouki Bazarbashi, Ashraf Warsi, Feras Alfraih, Abdualkreem Almoomen, Ahmed Osman, Tarek Owaidah   +6 more
doaj   +1 more source

New agents for DOAC reversal: a practical management review.

British Journal of Cardiology, 2022
Bleeding is the commonest and most concerning adverse event associated with anticoagulants. Bleeding, depending on the severity, is managed in various ways, and for severe or life-threatening bleeding, specific antidotes are indicated and recommended ...
Katie White, Uzma Faruqi, A. T. Cohen
semanticscholar   +1 more source

Safety of dabigatran in patients with atrial fibrillation and chronic kidney disease: pharmacokinetic and pharmacogenetic aspects

Медицинский совет, 2020
Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka, P. O. Bochkov, K. A. Akmalova, R. V. Shevchenko, P. M. Krupenin, V. V. Kogay, A. I. Listratov, A. S. Krainyaya, D. A. Napalkov, O. S. Gurinovich, A. A. Sokolova, V. V. Fomin, D. A. Sychev   +12 more
doaj   +1 more source

Direct oral anticoagulants (DOACs) [PDF]

Vascular Medicine, 2015
DOACs are a new group of blood-thinner medications that may have some advantages over warfarin. A health care provider will look at several different factors to help patients decide if a DOAC is a good choice. Patients taking DOACs should discuss medication changes, a plan for taking the DOAC before and after a surgery, and any bleeding side effects ...
Sara, Vazquez, Matthew T, Rondina
openaire   +2 more sources

Trends in direct oral anticoagulant (DOAC) prescribing in English primary care (2014–2019)

Heart, 2022
Background In England, most prescribing of direct-acting oral anticoagulants for atrial fibrillation (AF) is in primary care. However, there remain gaps in our understanding of dosage and disparities in use.
M. Joy, John Williams, S. Emanuel, D. Kar, Xuejuan Fan, G. Delanerolle, B. Field, C. Heiss, K. Pollock, B. Sandler, Jasleen Arora, J. Sheppard, M. Feher, F. R. Hobbs, S. de Lusignan   +14 more
semanticscholar   +1 more source

Novel Ex Vivo DOAC Removal Methods Reduce Interference in Lupus Anticoagulant Testing

Diagnostics, 2022
Direct oral anticoagulants (DOAC) interfere in laboratory coagulation testing. The aim here was to study how commercial DOAC removal methods, DOAC Filter® and DOAC-Stop™, perform to eliminate DOAC concentrations and false positive results in lupus ...
Paula Savola, Marja Lemponen, Lotta Joutsi-Korhonen, Tuukka A. Helin   +3 more
doaj   +1 more source