Results 81 to 90 of about 15,919 (234)

Conducting clinical lactation trials in the United Kingdom—Reflections from the New Horizons clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Jignesh P. Patel, Roopen Arya
wiley   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Do We Really Know How to Manage Anticoagulated Patients for Periodontal Nonsurgical Therapy? An Observational Cohort Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton, A. Rapani, F. Costantinides, V. Nicolin, D. Cuhureanu, R. Di Lenarda   +5 more
wiley   +1 more source

Potential usefulness of activated charcoal (DOAC remove®) for dRVVT testing in patients receiving Direct Oral AntiCoagulants

, 2019
International audienceIntroduction Lupus Anticoagulant testing using dilute Russell Viper Venom Time (dRVVT) is challenging in patients receiving Direct Oral AntiCoagulants (DOAC) due to potential false positive results.
Gaussem, Pascale, Jourdi, Georges, Stepanian, A., Foulon-Pinto, Geoffrey, Darnige, L., Siguret, V., Stepanian, Alain, Delrue, Maxime, Duchemin, Jerome, Gouin-Thibault, I., Demagny, Julien, Foulon-Pinto, G., Delavenne, X., Jourdi, G., Delavenne, Xavier, Gaussem, P., Darnige, Luc, Gouin-Thibault, Isabelle, Nedelec-Gac, F., Valaize, Jessica, Curis, Emmanuel, Nedelec-Gac, Fabienne, Curis, E., Duchemin, J., Valaize, J., Demagny, J., Siguret, Virginie, Delrue, M.   +27 more
core   +1 more source

Anti–factor Xa activity assays of direct‐acting oral anticoagulants during clinical care: An observational study

Research and Practice in Thrombosis and Haemostasis, 2021
Background Direct‐acting oral anticoagulants (DOACs) are increasingly used to prevent and treat thromboembolism. Although measurement of DOAC concentrations is not currently recommended as part of routine patient care, measurement of DOAC concentrations ...
Smrithi Sukumar, Melissa Cabero, Sharon Tiu, Margaret C. Fang, Scott C. Kogan, Janice B. Schwartz   +5 more
doaj   +1 more source

Performance Assessment of Staclot‐LA Assay on Fully Automated Coagulation Analyser for Lupus Anticoagulant Testing Using Internal and External Quality Controls

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction It is recommended to detect lupus anticoagulant (LA) using two phospholipid‐dependent clotting assays, including a LA‐sensitive activated partial‐thromboplastin‐time (aPTT). Among these reagents, Staclot‐LA assay is performed on a mixture of test and normal plasma with and without hexagonal phase phospholipids.
V. Siguret, G. Jourdi, S. Melicine, L. Goubeau, Q. Pomorski, B. Joly‐Laffargue, A. Stepanian, M. Delrue, C. Bon, P. Meijer, E. Curis   +10 more
wiley   +1 more source

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source

Evolving Mechanisms on Mortality in Atrial Fibrillation: A 25‐Year National Death‐Certificate Analysis

Journal of Cardiovascular Electrophysiology, EarlyView.
This 25‐year national analysis reveals a major shift in atrial fibrillation‐related mortality, driven by rapidly rising rates of heart failure and stroke‐free dementia. These trends underscore the urgent need to expand management beyond traditional stroke prevention to prioritize comprehensive heart failure care and cognitive health.
Jacqueline S. Dickey, Ashley Goodwin, Bobby Endo, Arthur Chen, Marc C. Engels, Klitos Konstantinidis, Immo Lehmann, Jose Roberto Martinez‐Parachini, Douglas L. Packer, Ravi Ranjan, Benjamin A. Steinberg, T. Jared Bunch   +11 more
wiley   +1 more source

Direct oral anticoagulants (DOAC) versus vitamin K antagonist in left ventricular thrombus: An updated meta‐analysis

, 2023
Background and Aims Current clinical guidelines for treating left ventricular thrombus (LVT) are limited by inadequate evidence to inform the comparative efficacy of oral anticoagulants.
Cory R. Trankle, George M. Bodziock, Toralben Patel, Rafae Shaikh, Bishal Dhakal, Jurgen Shtembari, Nimesh K. Patel, Dhan B. Shrestha, Sagun Dawadi, Ghanshyam Shantha   +9 more
core   +1 more source

The importance of dosing frequency on the safety of DOACs

American Heart Journal Plus: Cardiology Research and Practice, 2022
Direct oral anticoagulants (DOACs) represent a significant advance over vitamin K antagonists, such as warfarin in patients with atrial fibrillation (AF), due to their favorable risk-benefit profile, with significant reductions in stroke and serious bleeding, particularly intracranial hemorrhage.1 Although as class, DOACs tend to reduce major bleeding ...
openaire   +3 more sources